| Role of arterial wall properties in the pathogenesis of systolic hypertension. | |
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MedLine Citation:
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PMID: 15683728 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Recent prospective epidemiologic studies have directed attention to systolic blood pressure (SBP) as a better guide than diastolic blood pressure (DBP) to evaluate cardiovascular and all mortality, and recent data have underlined the importance of pulse pressure (PP) as an independent cardiovascular (CV) risk factors(5-7) in individuals more than 50 years of age. Furthermore, it has been shown that drug treatment of hypertension frequently results in adequate control of DBP, whereas control of SBP is achieved to a significantly smaller extent. Such studies have focused attention on the factors that determine the level of SBP and PP. Systolic blood pressure results from the interaction of three principal factors: 1) characteristics of left ventricular ejection (stroke volume); 2) cushioning (dampening) function of the large arteries (arterial stiffness); and 3) propagative and reflective properties of the arterial tree (intensity of wave reflections and timing of incident and reflected pressure waves). Considering the different mechanisms associated with increased SBP, individualized therapeutic approaches will require knowledge of the patient's unique profile of arterial stiffness and wave reflection characteristics. |
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Authors:
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Gérard M London |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: American journal of hypertension Volume: 18 ISSN: 0895-7061 ISO Abbreviation: Am. J. Hypertens. Publication Date: 2005 Jan |
Date Detail:
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Created Date: 2005-02-01 Completed Date: 2005-05-27 Revised Date: 2009-02-24 |
Medline Journal Info:
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Nlm Unique ID: 8803676 Medline TA: Am J Hypertens Country: United States |
Other Details:
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Languages: eng Pagination: 19S-22S Citation Subset: IM |
Affiliation:
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Department of Nephrology, Manhès Hospital, Fleury-Mérogis, France. glondon@club-internet.fr |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antihypertensive Agents
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therapeutic use Arteries / physiology Blood Pressure / drug effects, physiology Elasticity Humans Hypertension / drug therapy, etiology*, physiopathology Middle Aged Pulsatile Flow / physiology Pulse Risk Factors Stroke Volume / physiology Systole Vascular Resistance |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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