Document Detail


Role of arterial smooth muscle tone and geometry in the regulation of peripheral conduit artery mechanics by shear stress.
MedLine Citation:
PMID:  11903308     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
1. Although arterial blood flow is recognized as an important modulator of vascular tone and geometry, the effect of acute changes in shear-stress on conduit artery mechanics has not been fully investigated in humans because of technical limitations. 2. To assess, respectively, the effects of decreases and increases in flow and shear stress on radial artery tone and mechanics, arterial pressure (photoplethysmography), total blood viscosity, radial artery internal diameter, wall thickness (echotracking) and blood flow (Doppler) were measured in healthy volunteers (mean (+/-SEM) age 25 +/- 1 years) during a distal flow arrest (n=12) and hand skin heating (n=18). 3. Radial artery flow decreased from 31 +/- 4 to 7 +/- 1 10(-3) L/min during distal flow arrest (P < 0.001) and increased from 10 +/- 2 to 22 +/- 4 and 69 +/- 6 10(-3) L/min during heating (P < 0.001). At mean arterial pressure, these changes in flow were respectively associated with a parallel flow-dependent reduction and increase in diameter and midwall stress. There was no significant modification in mean elastic modulus. Compliance did not change when flow decreased and only increased at the highest level of flow. Finally, the cross-sectional compliance and incremental modulus were fitted as functions of midwall stress. The decrease in flow was associated with an upward shift of the modulus-midwall stress curve and a downward shift of the compliance-midwall stress curve. The increase in flow was associated with a downward shift of the modulus-midwall stress curve and an upward shift of the compliance-midwall stress curve at each level of wall shear stress. 4. By using two different procedures, we obtained similar results concerning the direct effects of increases and decreases in flow on stiffness of the arterial wall and on arterial compliance and demonstrated the presence of a flow-dependent regulation of arterial smooth muscle tone of peripheral conduit arteries in humans.
Authors:
R Joannides; A Costentin; M Iacob; el-H Bakkali; M O Richard; C Thuillez
Related Documents :
2568458 - The effect of lactose particle size on the extrusion properties of microcrystalline cel...
19378688 - Plaque and shear stress distribution in human coronary bifurcations: a multislice compu...
20459208 - Analysis of flow patterns in a patient-specific aortic dissection model.
10195928 - Temporal gradient in shear but not steady shear stress induces pdgf-a and mcp-1 express...
10463868 - Role of nitric oxide in mediating retinal blood flow regulation in cats.
9219468 - Clinical importance of measuring coronary graft flows in the revascularized heart. ultr...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical and experimental pharmacology & physiology     Volume:  28     ISSN:  0305-1870     ISO Abbreviation:  Clin. Exp. Pharmacol. Physiol.     Publication Date:  2001 Dec 
Date Detail:
Created Date:  2002-03-20     Completed Date:  2002-08-23     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0425076     Medline TA:  Clin Exp Pharmacol Physiol     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  1025-31     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, INSERM E9920, IFRMP 23, Rouen University Hospital, Rouen, France. robinson.joannides@chu-rouen.fr
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Blood Flow Velocity
Blood Viscosity
Compliance
Female
Hand / blood supply
Hot Temperature
Humans
Male
Muscle Tonus / physiology*
Muscle, Smooth, Vascular / anatomy & histology*,  physiology*
Radial Artery / physiology*
Regional Blood Flow / physiology*
Stress, Mechanical
Vasoconstriction
Vasodilation

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Alcohol and endothelial function: a brief review.
Next Document:  Vasculoprotective effects of oestrogens.