Document Detail

Role of arsenic as a reproductive toxin with particular attention to neural tube defects.
MedLine Citation:
PMID:  8656449     Owner:  NLM     Status:  MEDLINE    
Arsenic has been recognized as a human toxicant for over 2000 years. More recently it has been readily accepted as a human carcinogen. Animal research has demonstrated arsenic's ability to have profound detrimental effects on the developing embryo in avian and mammalian species. This article comprehensively reviews the human and animal literature on the subject of the reproductive toxicity of arsenic. A variety of endpoints are considered, including spontaneous abortion, cardiovascular defects, and arsenic's role in the causation of neural tube defects (NTDs). A summary of the literature that has examined the various postulated mechanisms by which arsenic may produce NTDs is also considered. In addition, a discussion of literature relative to the presence of arsenic in the general environment and in the workplace is presented. This article reaches the conclusion that while further research is clearly needed, particularly on the potential toxicity of organic arsenical compounds, the current literature suggests it may be prudent and appropriate to treat inorganic arsenic as a probable human reproductive toxin.
S L Shalat; D B Walker; R H Finnell
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Journal of toxicology and environmental health     Volume:  48     ISSN:  0098-4108     ISO Abbreviation:  J Toxicol Environ Health     Publication Date:  1996 Jun 
Date Detail:
Created Date:  1996-07-30     Completed Date:  1996-07-30     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7513622     Medline TA:  J Toxicol Environ Health     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  253-72     Citation Subset:  IM    
Department of Veterinary Anatomy and Public Health, College of Veterinary Medicine, Faculty of Toxicology, Texas A&M Health Science Center, Texas A&M University, College Station 77843-4458, USA.
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MeSH Terms
Arsenic / toxicity*
Environmental Exposure
Neural Tube Defects / chemically induced*,  epidemiology,  etiology,  genetics
Poisons / toxicity*
Reproduction / drug effects*
Teratogens / toxicity
Grant Support
Reg. No./Substance:
0/Poisons; 0/Teratogens; 7440-38-2/Arsenic

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