Document Detail


Role of antisecretory agents for gastric endoscopic submucosal dissection.
MedLine Citation:
PMID:  23368844     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Gastric endoscopic submucosal dissection (ESD) causes artificial gastric ulcers and there is no consensus regarding the optimal perioperative management in terms of prevention of intra- or postoperative bleeding and promotion of healing. Traditionally, 8-week administration of proton pump inhibitors (PPI) and mucosal protective agents were used in the same way as for peptic ulcer management. However, recent studies have revealed that prior use of PPI might reduce intraoperative bleeding or early-phase postoperative bleeding, and combination of histamine-2 receptor antagonist (H2RA), and second-look endoscopy might have a similar effect on postoperative bleeding to PPI. Additionally, the advantage of PPI over H2RA is not proven and the optimal duration of PPI may be shortened until 2 weeks when the deteriorating factors for ESD ulcer are excluded. Furthermore, mucosal protective agents may facilitate ulcer healing. Further studies are needed to determine the optimal treatment protocol before and after ESD for both prevention of bleeding complication and promotion of ulcer healing, by using available antisecretory agents and mucosal protective agents.
Authors:
Mitsuhiro Fujishiro; Philip Wy Chiu; Hsui-Po Wang
Related Documents :
22529074 - Indications for reverse shoulder replacement: a systematic review.
23447474 - Is rheumatic aetiology a predictor of poor outcome in the current era of mitral valve r...
12665084 - Cognitive-behavioral therapy plus contingency management for cocaine use: findings duri...
12450184 - Postoperative olfaction in chronic sinusitis: smokers versus nonsmokers.
19664504 - Poor outcomes after slap repair: descriptive analysis and prognosis.
23313934 - Effect of cyp3a4*18b polymorphisms and interactions with oprm1 a118g on postoperative f...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-24
Journal Detail:
Title:  Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society     Volume:  -     ISSN:  1443-1661     ISO Abbreviation:  Dig Endosc     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-2-1     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9101419     Medline TA:  Dig Endosc     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2013 The Authors. Digestive Endoscopy © 2013 Japan Gastroenterological Endoscopy Society.
Affiliation:
Department of Endoscopy and Endoscopic Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  TWIST1, A novel androgen-regulated gene, is a target for NKX3-1 in prostate cancer cells.
Next Document:  [2Fe-2S] proteins in chlorosomes: CsmI and CsmJ participate in light-dependent control of energy tra...