Document Detail


Role of antioxidant enzymes in brain tumours.
MedLine Citation:
PMID:  10807983     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Erythrocyte antioxidant enzymes were analysed in 100 patients with intracranial neoplasm and in 47 controls. There was a significant decrease in RBC glutathione reductase (GRx) and superoxide dismutase (SOD) activity in most types of brain tumor cases. Patients with acoustic neurinoma showed a significant reduction in selenium-dependent glutathione peroxidase (Se-GPx) activity. A decrease in catalase (CT) activity was seen in most of the brain tumor patients but remained statistically insignificant when compared to controls. A significant increase in plasma ceruloplasmin concentration was observed in patients with glioma. These enzymes were also studied in 27 post-treatment cases. GRx activity returned to normal levels in these patients. RBC SOD and plasma ceruloplasmin levels showed a tendency to return to normal. Hence, a marked decrease in the antioxidant enzymes may have a role in the genesis of considerable oxidative stress in patients with brain tumors.
Authors:
G M Rao; A V Rao; A Raja; S Rao; A Rao
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinica chimica acta; international journal of clinical chemistry     Volume:  296     ISSN:  0009-8981     ISO Abbreviation:  Clin. Chim. Acta     Publication Date:  2000 Jun 
Date Detail:
Created Date:  2000-07-14     Completed Date:  2000-07-14     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  1302422     Medline TA:  Clin Chim Acta     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  203-12     Citation Subset:  IM    
Affiliation:
Department of Biochemistry, Kasturba Medical College, Mangalore, India.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Aged, 80 and over
Antioxidants / metabolism*
Brain Neoplasms / enzymology*
Catalase / blood
Ceruloplasmin / analysis
Erythrocytes / enzymology
Female
Glioma / enzymology
Glutathione Peroxidase / blood
Glutathione Reductase / blood
Humans
Male
Meningioma / enzymology
Middle Aged
Neuroma, Acoustic / enzymology
Selenium / pharmacology
Superoxide Dismutase / blood
Chemical
Reg. No./Substance:
0/Antioxidants; 7782-49-2/Selenium; EC 1.11.1.6/Catalase; EC 1.11.1.9/Glutathione Peroxidase; EC 1.15.1.1/Superoxide Dismutase; EC 1.16.3.1/Ceruloplasmin; EC 1.8.1.7/Glutathione Reductase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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