Document Detail


Role of antifungal agents in the treatment of seborrheic dermatitis.
MedLine Citation:
PMID:  15663338     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Seborrheic dermatitis is a superficial fungal disease of the skin, occurring in areas rich in sebaceous glands. It is thought that an association exists between Malassezia yeasts and seborrheic dermatitis. This may, in part, be due to an abnormal or inflammatory immune response to these yeasts. The azoles represent the largest class of antifungals used in the treatment of this disease to date. In addition to their antifungal properties, some azoles, including bifonazole, itraconazole, and ketoconazole, have demonstrated anti-inflammatory activity, which may be beneficial in alleviating symptoms. Other topical antifungal agents, such as the allylamines (terbinafine), benzylamines (butenafine), hydroxypyridones (ciclopirox), and immunomodulators (pimecrolimus and tacrolimus), have also been effective. In addition, recent studies have revealed that tea tree oil (Melaleuca oil), honey, and cinnamic acid have antifungal activity against Malassezia species, which may be of benefit in the treatment of seborrheic dermatitis. In cases where seborrheic dermatitis is widespread, the use of an oral therapy, such as ketoconazole, itraconazole, and terbinafine, may be preferred. Essentially, antifungal therapy reduces the number of yeasts on the skin, leading to an improvement in seborrheic dermatitis. With a wide availability of preparations, including creams, shampoos, and oral formulations, antifungal agents are safe and effective in the treatment of seborrheic dermatitis.
Authors:
Aditya K Gupta; Karyn Nicol; Roma Batra
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  American journal of clinical dermatology     Volume:  5     ISSN:  1175-0561     ISO Abbreviation:  Am J Clin Dermatol     Publication Date:  2004  
Date Detail:
Created Date:  2005-01-24     Completed Date:  2005-05-12     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  100895290     Medline TA:  Am J Clin Dermatol     Country:  New Zealand    
Other Details:
Languages:  eng     Pagination:  417-22     Citation Subset:  IM    
Affiliation:
Division of Dermatology, Department of Medicine, Sunnybrook and Women's College Health Science Center (Sunnybrook site) and the University of Toronto, Toronto, Ontario, Canada. agupta@execulink.com
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MeSH Terms
Descriptor/Qualifier:
Administration, Cutaneous
Administration, Oral
Antifungal Agents / administration & dosage*,  pharmacology
Dermatitis, Seborrheic / drug therapy*,  microbiology
Humans
Malassezia / drug effects
Microbial Sensitivity Tests
Treatment Outcome
Chemical
Reg. No./Substance:
0/Antifungal Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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