Document Detail

Role of anti-thrombotic therapy for recurrent pregnancy loss due to anti-phospholipid syndrome.
MedLine Citation:
PMID:  22338455     Owner:  NLM     Status:  In-Process    
BACKGROUND: Recurrent pregnancy loss is a major health problem effecting 1(see symbol) 2% of women of reproductive age. Its causes range from chromosomal abnormalities to endocrinological factors and thrombophilia related factors. Treating thrombophilias especially antiphospholipid syndrome with low dose aspirin and low molecular weight heparin improves foetal outcome. This study will add local data to already existing knowledge.
METHOD: Sixty selected patients from gynaecology OPD of Aero Hospital with clinical and/or serological findings of antiphospholipid syndrome from February 2009 to January 2011 were given aspirin 75 mg once daily and enoxaparine 40 mg subcutaneously once daily from 6-8 weeks to 35 and 37 weeks respectively.
RESULTS: Ninety-three percent of patients achieved live birth. Out of these 75% patients delivered at term and 18% had preterm delivered. Four (7%) had early pregnancy loss and only one had early neonatal death due to extreme prematurity. None of patients experienced any major hemorrhagic complications.
CONCLUSION: Use of low dose aspirin and low molecular weight heparin is safe in pregnancy and improve foetal outcome in patients with recurrent pregnancy loss due to antiphospholipids syndrome.
Saadia Fawad
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of Ayub Medical College, Abbottabad : JAMC     Volume:  22     ISSN:  1025-9589     ISO Abbreviation:  J Ayub Med Coll Abbottabad     Publication Date:    2010 Jul-Sep
Date Detail:
Created Date:  2012-02-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8910750     Medline TA:  J Ayub Med Coll Abbottabad     Country:  Pakistan    
Other Details:
Languages:  eng     Pagination:  197-200     Citation Subset:  IM    
Department of Gynaecology, Aero Hospital, Air Weapon Complex Hassanabdal, Pakistan.
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