Document Detail

Role of anti-β(1) adrenergic antibodies from patients with periodontitis in cardiac dysfunction.
MedLine Citation:
PMID:  21958237     Owner:  NLM     Status:  Publisher    
J Oral Pathol Med (2011) Background:  The presence of serum autoantibodies against β(1) adrenoreceptors (β(1) -ARs) in human gingival fibroblast from patients with periodontitis inhibits primary cell-specific growth and induces over-expression of pro-inflammatory mediators. Serum β(1) -AR autoantibodies from patients with periodontitis react with myocardium and modify cardiac contractility. The relationship between the presence of serum β(1) -AR autoantibodies and alterations in heart rate variability (HRV) was also studied. Methods:  An enzyme-linked immunosorbent assay (ELISA) using cardiac and gingival fibroblast membranes or synthetic peptides corresponding to the second extracellular loop of human β(1) -AR was used to detect serum autoantibodies. The HRV was assessed from RR interval files generated from 22:00 to 08:00 hours. The autoantibody effects on contractility were measured on spontaneous rat isolated atria. Results:  Circulating autoantibodies from 36 patients with periodontitis and 20 healthy individuals (controls) interacted with fibroblasts, the cardiac surface, and β(1) -AR synthetic peptides. The distributions of serum antibodies against gingival and myocardium membranes and β(1) -AR synthetic peptide were 88.8%, 77.7%, and 92.8%, respectively. Moreover, 88.5% of patients with periodontitis whose sera were positive against β(1) -AR synthetic peptide had decreased HRV. The corresponding affinity-purified anti-β(1) -AR peptide IgG displayed partial agonist-like activity modifying the isolated atria contractility. Conclusion:  This manuscript describes that patients with periodontitis showed increased levels of serum IgG with reactive activity against β(1) -AR. Those patients demonstrated decrease in heart rate, and IgG derived from their sera induced aberrant contractility of heart atrium. We propose that periodontitis increases the risk of cardiovascular diseases, although it increases anti-β(1) -AR autoantibody that alters myocardial contractility.
Marcela Segovia; Sabrina Ganzinelli; Silvia Reina; Enri Borda; Leonor Sterin-Borda
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-9-30
Journal Detail:
Title:  Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology     Volume:  -     ISSN:  1600-0714     ISO Abbreviation:  -     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-9-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8911934     Medline TA:  J Oral Pathol Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2011 John Wiley & Sons A/S.
Pharmacology Unit, School of Dentistry, Buenos Aires University, Buenos Aires, Argentina Argentine National Research Council (CONICET), Buenos Aires, Argentina.
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