| Role of angiotensin in the rostral ventrolateral medulla in the development and maintenance of hypertension. | |
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MedLine Citation:
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PMID: 21269877 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Whilst crucial for behavioural and homeostatic responses to environmental challenges, chronic elevation of sympathetic nervous system activity to specific vascular beds is associated with hypertension. Indeed such elevated activity may drive the increase in blood pressure seen in some people and in some experimental models of hypertension. This review discusses the neural circuitry involved in generating and modulating sympathetic efferent nerve activity, focusing on the premotor neurons of the rostral ventrolateral medulla. Neurons in the rostral ventrolateral medulla show altered responses to angiotensin II in experimental models of hypertension, suggesting that this might be an important node for interaction between these two systems that are crucial for regulation of blood pressure. |
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Authors:
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Andrew M Allen |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-1-24 |
Journal Detail:
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Title: Current opinion in pharmacology Volume: - ISSN: 1471-4973 ISO Abbreviation: - Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-1-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100966133 Medline TA: Curr Opin Pharmacol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011. Published by Elsevier Ltd. |
Affiliation:
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Department of Physiology and Florey Neurosciences Institutes, University of Melbourne, Vic., 3010, Australia. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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