| Role of angiotensin II in the evolution of diastolic heart failure. | |
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MedLine Citation:
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PMID: 16330897 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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More than half of all persons with heart failure (HF) have diastolic HF. The prevalence of diastolic HF increases from 46% in persons younger than 45 years to 59% in those 85 years and older. The annual mortality rate associated with diastolic HF is >10%. Diagnosis is based on signs and symptoms of HF, elevated plasma B-type natriuretic peptide, preserved left ventricular systolic function, and evidence of diastolic dysfunction by Doppler examination on two-dimensional echocardiography. Approximately 80% of patients with diastolic HF have increased left ventricular mass and a history of hypertension. Neurohormonal activation is a key aspect of this condition. Studies suggest that activation of the renin-angiotensin-aldosterone system, specifically direct cardiac effects of angiotensin II and aldosterone, contributes to the pathogenesis and progression of diastolic dysfunction. Hence, there is a rationale for use of agents that antagonize the renin-angiotensin-aldosterone system, such as angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, and aldosterone antagonists, in patients with heart failure. |
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Authors:
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Kavitha M Chinnaiyan; Daniel Alexander; Peter A McCullough |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Journal of clinical hypertension (Greenwich, Conn.) Volume: 7 ISSN: 1524-6175 ISO Abbreviation: J Clin Hypertens (Greenwich) Publication Date: 2005 Dec |
Date Detail:
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Created Date: 2005-12-06 Completed Date: 2007-04-10 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 100888554 Medline TA: J Clin Hypertens (Greenwich) Country: United States |
Other Details:
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Languages: eng Pagination: 740-7 Citation Subset: IM |
Affiliation:
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Division of Cardiology and Nutrition, William Beaumont Hospital, Royal Oak, MI 48073, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aldosterone Antagonists
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pharmacology,
therapeutic use Angiotensin II / physiology* Angiotensin-Converting Enzyme Inhibitors / pharmacology, therapeutic use Blood Pressure / physiology Heart Failure / drug therapy, etiology*, mortality Humans Hypertension / complications Hypertrophy, Left Ventricular / etiology Prognosis Receptors, Angiotensin / antagonists & inhibitors Renal Insufficiency / complications Renin-Angiotensin System / drug effects, physiology Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Aldosterone Antagonists; 0/Angiotensin-Converting Enzyme Inhibitors; 0/Receptors, Angiotensin; 11128-99-7/Angiotensin II |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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