Document Detail


Role of angiotensin II and bradykinin on aortic collagen following converting enzyme inhibition in spontaneously hypertensive rats.
MedLine Citation:
PMID:  9409311     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We previously showed that chronic angiotensin-converting enzyme (ACE) inhibition prevented the increase in aortic collagen in spontaneously hypertensive rats (SHRs) independently of blood pressure reduction. The aim of the present study was to determine whether the effects of ACE inhibition on aortic fibrosis were due to inhibition of angiotensin II formation, preservation of bradykinin, or a combination of both. Four week-old SHRs were treated for 4 months with the ACE inhibitor quinapril, quinapril with the bradykinin B2 receptor antagonist Hoe 140, or the angiotensin II AT1 receptor antagonist CI996. Control SHR and Wistar-Kyoto (WKY) rats received a placebo for the same period of time. At the end of the treatment, as compared to conscious SHR and WKY controls, quinapril completely prevented the development of hypertension, whereas quinapril-Hoe 140 and the AT1 receptor antagonist produced only a partial reduction of blood pressure. In relation with blood pressure changes, aortic hypertrophy was significantly prevented by quinapril but not by quinapril-Hoe 140 or CI996. In contrast, aortic collagen accumulation was completely prevented by all three treatments. The study provides evidence that in young live SHRs, the prevention of aortic collagen accumulation is independent of blood pressure changes and bradykinin preservation and involves exclusively angiotensin II inhibition through AT1 receptors.
Authors:
A Benetos; B I Levy; P Lacolley; F Taillard; M Duriez; M E Safar
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Arteriosclerosis, thrombosis, and vascular biology     Volume:  17     ISSN:  1079-5642     ISO Abbreviation:  Arterioscler. Thromb. Vasc. Biol.     Publication Date:  1997 Nov 
Date Detail:
Created Date:  1998-01-22     Completed Date:  1998-01-22     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9505803     Medline TA:  Arterioscler Thromb Vasc Biol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  3196-201     Citation Subset:  IM    
Affiliation:
Unit 337, INSERM, Paris, France.
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MeSH Terms
Descriptor/Qualifier:
Angiotensin II / antagonists & inhibitors,  physiology*
Angiotensin-Converting Enzyme Inhibitors / administration & dosage,  pharmacology*,  therapeutic use
Animals
Aorta, Thoracic / drug effects*,  metabolism,  pathology
Bradykinin / administration & dosage,  analogs & derivatives*,  antagonists & inhibitors,  pharmacology,  physiology*,  therapeutic use
Collagen / metabolism*
Drug Therapy, Combination
Hemodynamics / drug effects
Hypertension / drug therapy,  genetics,  metabolism*,  prevention & control
Hypertrophy
Imidazoles / administration & dosage,  pharmacology*,  therapeutic use
Isoquinolines / administration & dosage,  pharmacology*,  therapeutic use
Male
Rats
Rats, Inbred SHR
Rats, Inbred WKY
Receptor, Angiotensin, Type 1
Receptor, Angiotensin, Type 2
Receptor, Bradykinin B2
Receptors, Angiotensin / antagonists & inhibitors
Receptors, Bradykinin / antagonists & inhibitors
Tetrahydroisoquinolines*
Tetrazoles / administration & dosage,  pharmacology*,  therapeutic use
Chemical
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 0/CI 996; 0/Imidazoles; 0/Isoquinolines; 0/Receptor, Angiotensin, Type 1; 0/Receptor, Angiotensin, Type 2; 0/Receptor, Bradykinin B2; 0/Receptors, Angiotensin; 0/Receptors, Bradykinin; 0/Tetrahydroisoquinolines; 0/Tetrazoles; 11128-99-7/Angiotensin II; 130308-48-4/icatibant; 58-82-2/Bradykinin; 82586-55-8/quinapril; 9007-34-5/Collagen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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