Document Detail

Role of androgen on blood flow and capillary structure in rat seminal vesicles.
MedLine Citation:
PMID:  15065645     Owner:  NLM     Status:  MEDLINE    
To clarify the effect of androgen on the microcirculation in seminal vesicles of adult Wistar rats, we investigated the organ blood flow and morphological features in the capillaries after castration and subsequent testosterone supplementation. Testosterone (T) was subcutaneously injected every 12 hours after castration and its doses were set to 10(-2), 10(-1), 10(0) and 10(1) mg/kg-body weight (T10(-2), T10(-1), T10(0) and T10(1) groups, respectively). Organ blood flow was measured using laser Doppler flowmetry, and the subepithelial capillaries were analyzed using transmission electron microscopy. The capillaries were morphologically classified into 3 types; oval opened (type 1), intermediate (type 2) and collapsed (type 3), and their luminal areas were measured using a computed image analyzer. The organ blood flow was significantly reduced from 36.3+/-5.1 to 21.9+/-2.7 ml x min(-1)/100 g tissue, and the luminal area of the capillaries was significantly reduced from 9.02+/-1.28 to 4.85+/-0.82 microm2 with the shift of the type 1 and type 2 to type 3 after castration. The reduction of the luminal area and the blood flow reduction, and shift of the capillary type were significantly protected by gradated testosterone supplementation. These results indicate that the maintenance of the blood flow and morphological profiles in capillaries depend on androgen-supplementation levels in seminal vesicles.
Yoshihiro Ono; Kazuhiro Suzuki; Bunzo Kashiwagi; Yasuhiro Shibata; Kazuto Ito; Yoshitatsu Fukabori; Hidetoshi Yamanaka
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Tohoku journal of experimental medicine     Volume:  202     ISSN:  0040-8727     ISO Abbreviation:  Tohoku J. Exp. Med.     Publication Date:  2004 Mar 
Date Detail:
Created Date:  2004-04-06     Completed Date:  2004-10-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0417355     Medline TA:  Tohoku J Exp Med     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  193-201     Citation Subset:  IM    
Department of Urology, Gunma University School of Medicine, Maebashi 371-8511, Japan.
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MeSH Terms
Capillaries / drug effects,  metabolism,  ultrastructure*
Laser-Doppler Flowmetry
Rats, Wistar
Regional Blood Flow / drug effects
Seminal Vesicles / blood supply*,  drug effects,  ultrastructure
Testosterone / pharmacology*
Reg. No./Substance:

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