Document Detail


Role of aluminum hydroxide in raising serum aluminum levels in children undergoing continuous ambulatory peritoneal dialysis.
MedLine Citation:
PMID:  6502300     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Serum aluminum concentrations were measured in 16 children undergoing continuous ambulatory peritoneal dialysis after 7.9 +/- 2.1 (mean +/- SE) and 16.6 +/- 2.3 months of therapy, when the estimated simultaneous oral Al intake from Al hydroxide gels was 98 +/- 20 and 104 +/- 32 mg/kg/day, respectively. Serum Al concentrations were 55.2 +/- 11.4 and 59.8 +/- 10.4 micrograms/L, respectively, compared to 8.2 +/- 1.1 micrograms/L in normal children (P less than 0.001). Serum Al levels correlated with oral Al intake (r = 0.86, P less than 0.001) and inversely with body weight (r = -0.68, P less than 0.01) and age (r = -0.67, P less than 0.01). The youngest patient with the highest serum Al concentrations (208 and 174 micrograms/L) and greatest Al intake (310 and 192 mg/kg/day) had bone biopsy features characteristic of aluminum-related bone disease. Thus, higher aluminum intake per kilogram body weight given to young children is likely to raise the serum Al levels and increase the risk of osteomalacia. Aluminum-containing antacids should be used with caution in infants and young children with renal failure.
Authors:
I B Salusky; J W Coburn; L Paunier; D J Sherrard; R N Fine
Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  105     ISSN:  0022-3476     ISO Abbreviation:  J. Pediatr.     Publication Date:  1984 Nov 
Date Detail:
Created Date:  1984-12-27     Completed Date:  1984-12-27     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  717-20     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Adolescent
Aluminum / blood*
Aluminum Hydroxide / administration & dosage,  adverse effects*
Bone Development / drug effects
Child
Child, Preschool
Female
Humans
Infant
Male
Osteomalacia / chemically induced,  pathology
Peritoneal Dialysis* / adverse effects
Peritoneal Dialysis, Continuous Ambulatory* / adverse effects
Grant Support
ID/Acronym/Agency:
AM 28368/AM/NIADDK NIH HHS; AM 29926/AM/NIADDK NIH HHS
Chemical
Reg. No./Substance:
21645-51-2/Aluminum Hydroxide; 7429-90-5/Aluminum

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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