| Role of alpha1-antitrypsin and detoxification functions of the liver in the pathogenesis of endotoxin-induced fever. | |
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MedLine Citation:
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PMID: 11140575 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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CCl4-induced toxic damage to the liver in rats and rabbits is accompanied by inhibition of detoxifying functions of the liver and a decrease in plasma alpha1-antitrypsin content and core body temperature. Injection of pyrogenal stimulated detoxifying functions of the liver, elevated alpha1-antitrypsin content in the blood, and increased body temperature. Intravenous injection of alpha1-antitrypsin caused hyperthermia. No pyrogenal-induced hyperthermia was observed in animals with CC4-induced damage to the liver. These data indicate that functional activity of the liver and blood content of alpha1-antitrypsin play an important role in the mechanisms of thermoregulatory reactions to endotoxin. |
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Authors:
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F I Vismont; O G Shust |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Bulletin of experimental biology and medicine Volume: 130 ISSN: 0007-4888 ISO Abbreviation: Bull. Exp. Biol. Med. Publication Date: 2000 Jul |
Date Detail:
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Created Date: 2001-01-03 Completed Date: 2001-02-15 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0372557 Medline TA: Bull Exp Biol Med Country: United States |
Other Details:
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Languages: eng Pagination: 645-6 Citation Subset: IM |
Affiliation:
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Department of Pathophysiology, Minsk State Medical Institute. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Carbon Tetrachloride / toxicity Endotoxins / toxicity* Female Fever / chemically induced* Liver / drug effects, physiopathology* Male Rabbits Rats alpha 1-Antitrypsin / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Endotoxins; 0/alpha 1-Antitrypsin; 56-23-5/Carbon Tetrachloride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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