Document Detail

Role of alpha-galactosylceramide-activated Valpha14 natural killer T cells in the regulation of allergic diseases.
MedLine Citation:
PMID:  17259803     Owner:  NLM     Status:  MEDLINE    
Valpha14 natural killer T (NKT) cells produce large amounts of both IL-4 and IFN-gamma upon stimulation with a ligand, alpha-galactosylceramide (alpha-GalCer), and play a crucial role in various immune responses, including allergic reactions. Interestingly, Valpha14 NKT cells are not essential for the induction of specific IgE response but they instead tend to induce suppression of specific IgE upon alpha-GalCer activation in vivo. The suppression in the IgE production is not detected either in Valpha14 NKT cell-deficient mice or in IFN-gamma-deficient mice. Therefore, activated Valpha14 NKT cells are able to exert a potent suppressive activity on Th2 cell differentiation and subsequent IgE production by producing a large amount of IFN-gamma. In an OVA-induced asthma model, alpha-GalCer administration inhibited airway inflammation and airway hyperreactivity by IFN-gamma from activated Valpha14 NKT cells, thus suggesting the negative regulation of Th2-responses by the activated Valpha14 NKT cells.
Chiaki Iwamura; Toshinori Nakayama
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2007-01-29
Journal Detail:
Title:  Allergology international : official journal of the Japanese Society of Allergology     Volume:  56     ISSN:  1323-8930     ISO Abbreviation:  Allergol Int     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-02-23     Completed Date:  2007-06-05     Revised Date:  2008-03-06    
Medline Journal Info:
Nlm Unique ID:  9616296     Medline TA:  Allergol Int     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  1-6     Citation Subset:  IM    
Department of Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan.
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MeSH Terms
Antigens, Differentiation, B-Lymphocyte / immunology
Cell Differentiation / immunology
Galactosylceramides / immunology*
Histocompatibility Antigens Class II / immunology
Hypersensitivity / immunology*
Killer Cells, Natural / immunology*
Lymphocyte Activation / immunology*
Receptors, Immunologic / immunology*
T-Lymphocyte Subsets / immunology*
Th1 Cells / cytology,  immunology
Th2 Cells / cytology,  immunology
Reg. No./Substance:
0/Antigens, Differentiation, B-Lymphocyte; 0/Galactosylceramides; 0/Histocompatibility Antigens Class II; 0/Receptors, Immunologic; 0/alpha-galactosylceramide; 0/invariant chain

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