Document Detail

Role of alpha-adrenergic coronary tone in exercise-induced angina pectoris.
MedLine Citation:
PMID:  2868648     Owner:  NLM     Status:  MEDLINE    
To provide more insight into the role of alpha-adrenergic coronary tone in exercise-induced angina, 9 patients with chronic stable angina underwent after coronary angiography a symptom-limited supine exercise test on a cyclo-ergometer. After recovery, phentolamine was directly injected into the most diseased vessel (2 mg in 5 minutes), and immediately thereafter the same exercise (identical workloads and exercise duration) was repeated. During exercise 1, heart rate (HR), mean blood pressure and cardiac index increased 51% (p less than 0.001), 23% (p less than 0.01) and 33% (p less than 0.01), respectively, and pulmonary artery wedge pressure (PA wedge) increased from 9 +/- 1 to 26 +/- 2 mm Hg (p less than 0.001). After intracoronary injection of phentolamine, control values (including PA wedge) at rest did not change significantly. During exercise 2, HR, mean blood pressure and cardiac index increased in a similar way--50% (p less than 0.001), 25% (p less than 0.01) and 40% (p less than 0.01), respectively; however the increase in PA wedge was less (p less than 0.01). ST-segment depression at the end of exercise 2 was smaller for identical workloads and double products: 1.5 +/- 0.3 mm vs 2.5 +/- 0.3 mm (p less than 0.01). ST/HR slope in exercise 2 also decreased 51% (p less than 0.01). These results show a less severe ischemic response after intracoronary alpha blockade and argue for an improvement in coronary blood supply.
G M Berkenboom; M Abramowicz; P Vandermoten; S G Degre
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of cardiology     Volume:  57     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  1986 Feb 
Date Detail:
Created Date:  1986-03-12     Completed Date:  1986-03-12     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  195-8     Citation Subset:  AIM; IM; S    
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MeSH Terms
Adrenergic alpha-Antagonists / diagnostic use
Angina Pectoris / etiology*,  physiopathology
Blood Pressure
Cardiac Output
Coronary Angiography
Coronary Circulation
Coronary Vessels / drug effects*,  physiopathology
Exercise Test
Heart Rate
Middle Aged
Phentolamine / diagnostic use*
Physical Exertion*
Receptors, Adrenergic, alpha / drug effects,  physiology*
Reg. No./Substance:
0/Adrenergic alpha-Antagonists; 0/Receptors, Adrenergic, alpha; 50-60-2/Phentolamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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