Document Detail


Role of alpha 1-adrenoceptor activity in progression of cardiac hypertrophy in guinea pig hearts with pressure overload.
MedLine Citation:
PMID:  2574075     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To elucidate the role of alpha 1- and beta-adrenergic activities in pressure overload hypertrophy, changes of alpha 1- and beta-adrenoceptors were measured by radioligand binding assay, and the preventive effects of alpha 1- and beta-adrenoceptor blockade on cardiac hypertrophy were assessed in guinea pigs after aortic banding. Five days after banding, dry weight of left ventricle had not increased, though wet weight increased due to marked intercellular oedema. In this period, the maximum binding capacity of [3H] prazosin increased to 31.1 (SEM 2.2) fmol.mg-1 from (sham operation) 17.0(2.1) fmol.mg protein-1, p less than 0.01, whereas the maximum binding capacity of [3H]dihydroalprenolol did not increase: 143(16) fmol.mg-1 (banded) v 153(13) fmol.mg-1 (sham). Three weeks after aortic banding, the maximum binding capacity of both ligands increased to 45.6(5.5) fmol.mg-1 and 232(21) fmol.mg-1, respectively, accompanied by a significant increase in left ventricular dry weight, from 0.46(0.02) mg.g-1 (sham) to 0.62(0.08) mg.g-1 (banded), p less than 0.01. Continuous subcutaneous administration of the alpha 1-blocker bunazosin (0.1 mg.kg-1.d-1) significantly attenuated the increase in left ventricular dry weight whereas the beta-blocker propranolol (5 mg.kg-1.d-1) did not: 0.55(0.03) v 0.66(0.04) mg.g-1 respectively, after 3 weeks. These results show that pressure overload elicited an increase in myocardial alpha 1-adrenoceptors before the onset of cardiac hypertrophy, and that an alpha 1-blocker could prevent the development of hypertrophy in the pressure overloaded heart.
Authors:
J Tamai; M Hori; T Kagiya; K Iwakura; K Iwai; A Kitabatake; Y Watanabe; H Yoshida; M Inoue; T Kamada
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cardiovascular research     Volume:  23     ISSN:  0008-6363     ISO Abbreviation:  Cardiovasc. Res.     Publication Date:  1989 Apr 
Date Detail:
Created Date:  1990-01-25     Completed Date:  1990-01-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0077427     Medline TA:  Cardiovasc Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  315-22     Citation Subset:  IM    
Affiliation:
First Department of Medicine, Osaka University School of Medicine, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adrenergic alpha-Antagonists / pharmacology
Animals
Aorta
Cardiomegaly / physiopathology*
Constriction
Guinea Pigs
Heart Rate / drug effects
Heart Ventricles / analysis
Liver / pathology
Lung / pathology
Male
Myocardium / analysis,  pathology
Norepinephrine / analysis
Organ Size / drug effects
Propranolol / pharmacology
Receptors, Adrenergic, alpha / analysis,  physiology*
Receptors, Adrenergic, beta / analysis
Chemical
Reg. No./Substance:
0/Adrenergic alpha-Antagonists; 0/Receptors, Adrenergic, alpha; 0/Receptors, Adrenergic, beta; 51-41-2/Norepinephrine; 525-66-6/Propranolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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