Document Detail

Role of alpha 1-adrenoceptor activity in progression of cardiac hypertrophy in guinea pig hearts with pressure overload.
MedLine Citation:
PMID:  2574075     Owner:  NLM     Status:  MEDLINE    
To elucidate the role of alpha 1- and beta-adrenergic activities in pressure overload hypertrophy, changes of alpha 1- and beta-adrenoceptors were measured by radioligand binding assay, and the preventive effects of alpha 1- and beta-adrenoceptor blockade on cardiac hypertrophy were assessed in guinea pigs after aortic banding. Five days after banding, dry weight of left ventricle had not increased, though wet weight increased due to marked intercellular oedema. In this period, the maximum binding capacity of [3H] prazosin increased to 31.1 (SEM 2.2) from (sham operation) 17.0(2.1) protein-1, p less than 0.01, whereas the maximum binding capacity of [3H]dihydroalprenolol did not increase: 143(16) (banded) v 153(13) (sham). Three weeks after aortic banding, the maximum binding capacity of both ligands increased to 45.6(5.5) and 232(21), respectively, accompanied by a significant increase in left ventricular dry weight, from 0.46(0.02) mg.g-1 (sham) to 0.62(0.08) mg.g-1 (banded), p less than 0.01. Continuous subcutaneous administration of the alpha 1-blocker bunazosin (0.1 significantly attenuated the increase in left ventricular dry weight whereas the beta-blocker propranolol (5 did not: 0.55(0.03) v 0.66(0.04) mg.g-1 respectively, after 3 weeks. These results show that pressure overload elicited an increase in myocardial alpha 1-adrenoceptors before the onset of cardiac hypertrophy, and that an alpha 1-blocker could prevent the development of hypertrophy in the pressure overloaded heart.
J Tamai; M Hori; T Kagiya; K Iwakura; K Iwai; A Kitabatake; Y Watanabe; H Yoshida; M Inoue; T Kamada
Related Documents :
8884655 - Platelet i1-imidazoline binding sites are elevated in depression but not generalized an...
9307605 - Equilibrium versus compartmental analysis for assessment of the vesicular monoamine tra...
22801505 - Protein activity regulation by conformational entropy.
77165 - Oestrone binding properties of nine molecular variants of rat alpha-foetoprotein.
16312015 - Base-pairing potential identified by in vitro selection predicts the kinked rna backbon...
2906875 - Penbutolol: pharmacokinetics, effect on exercise tachycardia, and in vitro inhibition o...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cardiovascular research     Volume:  23     ISSN:  0008-6363     ISO Abbreviation:  Cardiovasc. Res.     Publication Date:  1989 Apr 
Date Detail:
Created Date:  1990-01-25     Completed Date:  1990-01-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0077427     Medline TA:  Cardiovasc Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  315-22     Citation Subset:  IM    
First Department of Medicine, Osaka University School of Medicine, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Adrenergic alpha-Antagonists / pharmacology
Cardiomegaly / physiopathology*
Guinea Pigs
Heart Rate / drug effects
Heart Ventricles / analysis
Liver / pathology
Lung / pathology
Myocardium / analysis,  pathology
Norepinephrine / analysis
Organ Size / drug effects
Propranolol / pharmacology
Receptors, Adrenergic, alpha / analysis,  physiology*
Receptors, Adrenergic, beta / analysis
Reg. No./Substance:
0/Adrenergic alpha-Antagonists; 0/Receptors, Adrenergic, alpha; 0/Receptors, Adrenergic, beta; 51-41-2/Norepinephrine; 525-66-6/Propranolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Effects of opiates during baroreceptor and ergoreceptor induced changes in blood pressure.
Next Document:  Transgenic mice expressing hamster prion protein produce species-specific scrapie infectivity and am...