| Role of aldosterone in left ventricular hypertrophy among African-American patients with end-stage renal disease on hemodialysis. | |
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MedLine Citation:
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PMID: 17317951 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: Recently, serum aldosterone levels have been reported to play a significant role in cardiac hypertrophy. One study of Japanese patients correlated aldosterone levels with the degree of left ventricular hypertrophy (LVH) in those undergoing hemodialysis. However, the role of aldosterone in LVH in non-Japanese patients with end-stage renal disease (ESRD) has not been established. MATERIALS AND METHODS: Researchers evaluated 42 [29 African-Americans (69%), 11 Caucasians (26%), and 2 other (5%)] male ESRD patients on dialysis for more than 6 months. Pre- and postdialysis, blood pressures and aldosterone and renin concentrations were measured. Transthoracic echocardiography was performed and left ventricular mass (LVM) index was calculated using the Devereaux formula. Medications were reviewed. RESULTS: There were no differences noted in medications prescribed for African-Americans and for Caucasians. Additionally, data from diabetic patients showed no statistically significant correlation between LVM index and any of the variables, including pre- and postdialysis blood pressure, serum potassium, renin, and aldosterone levels, for African-Americans compared to Caucasians. Data from nondiabetic patients showed a positive correlation between LVM and plasma aldosterone concentration in African-Americans (n = 10). Data from nondiabetic Caucasians were disregarded because only one was studied. CONCLUSION: LVM and aldosterone correlate in African-American males with ESRD on hemodialysis without diabetes. This has important implications for the etiology of, and therapy for LVH in this population. Larger studies are needed to determine whether the same associations exist in females and Caucasians. |
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Authors:
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Susan Steigerwalt; Abida Zafar; Nancy Mesiha; Julius Gardin; Robert Provenzano |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-02-23 |
Journal Detail:
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Title: American journal of nephrology Volume: 27 ISSN: 1421-9670 ISO Abbreviation: Am. J. Nephrol. Publication Date: 2007 |
Date Detail:
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Created Date: 2007-04-11 Completed Date: 2007-04-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8109361 Medline TA: Am J Nephrol Country: Switzerland |
Other Details:
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Languages: eng Pagination: 159-63 Citation Subset: IM |
Copyright Information:
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Copyright 2007 S. Karger AG, Basel. |
Affiliation:
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Division of Nephrology and Hypertension, Department of Medicine, St. John Hospital and Medical Center, Detroit, Mich 48236, USA. spspnhp@aol.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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African Americans Aged Aldosterone / blood* Diabetes Mellitus / blood European Continental Ancestry Group Humans Hypertension / blood, complications Hypertrophy, Left Ventricular / blood, complications, physiopathology* Kidney Failure, Chronic / blood, complications, physiopathology*, therapy Male Middle Aged Renal Dialysis |
| Chemical | |
Reg. No./Substance:
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52-39-1/Aldosterone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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