| Role of aldehyde dehydrogenases in endogenous and xenobiotic metabolism. | |
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MedLine Citation:
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PMID: 11154732 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Aldehydes are highly reactive molecules that are intermediates or products involved in a broad spectrum of physiologic, biologic and pharmacologic processes. Aldehydes are generated from chemically diverse endogenous and exogenous precursors and aldehyde-mediated effects vary from homeostatic and therapeutic to cytotoxic, and genotoxic. One of the most important pathways for aldehyde metabolism is their oxidation to carboxylic acids by aldehyde dehydrogenases (ALDHs). Oxidation of the carbonyl functional group is considered a general detoxification process in that polymorphisms of several human ALDHs are associated a disease phenotypes or pathophysiologies. However, a number of ALDH-mediated oxidation form products that are known to possess significant biologic, therapeutic and/or toxic activities. These include the retinoic acid, an important element for vertebrate development, gamma-aminobutyric acid (GABA), an important neurotransmitter, and trichloroacetic acid, a potential toxicant. This review summarizes the ALDHs with an emphasis on catalytic properties and xenobiotic substrates of these enzymes. |
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Authors:
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V Vasiliou; A Pappa; D R Petersen |
Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Chemico-biological interactions Volume: 129 ISSN: 0009-2797 ISO Abbreviation: Chem. Biol. Interact. Publication Date: 2000 Dec |
Date Detail:
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Created Date: 2001-02-09 Completed Date: 2001-02-15 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0227276 Medline TA: Chem Biol Interact Country: IRELAND |
Other Details:
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Languages: eng Pagination: 1-19 Citation Subset: IM |
Affiliation:
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Molecular Toxicology and Environmental Health Sciences Program, Department of Pharmaceutical Sciences, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA. vasilis.vasiliou@uchsc.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aldehyde Dehydrogenase
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classification,
genetics*,
metabolism* Aldehydes / metabolism Animals Carboxylic Acids / metabolism Humans Oxidation-Reduction Vertebrates Xenobiotics / pharmacokinetics* gamma-Aminobutyric Acid / metabolism |
| Grant Support | |
ID/Acronym/Agency:
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R01 AA09300/AA/NIAAA NIH HHS; R01 AA11885/AA/NIAAA NIH HHS; R29 EY11490/EY/NEI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Aldehydes; 0/Carboxylic Acids; 0/Xenobiotics; 56-12-2/gamma-Aminobutyric Acid; EC 1.2.1.3/Aldehyde Dehydrogenase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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