| Role of alanine-valine transaminase in Salmonella typhimurium and analysis of an avtA::Tn5 mutant. | |
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MedLine Citation:
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PMID: 6309735 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In Salmonella typhimurium, as in Escherichia coli, mutations in avtA, the gene encoding the alanine-valine transaminase (transaminase C), are silent unless they are combined with mutations involved in isoleucine-valine biosynthesis. avtA is repressed by leucine or alanine but not by valine. Transaminase C is found at reduced levels upon starvation for any one of several amino acids. We hypothesize that this is due to repression of avtA by the elevated alanine and leucine pools found in amino acid-starved cells. |
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Authors:
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C M Berg; W A Whalen; L B Archambault |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of bacteriology Volume: 155 ISSN: 0021-9193 ISO Abbreviation: J. Bacteriol. Publication Date: 1983 Sep |
Date Detail:
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Created Date: 1983-10-21 Completed Date: 1983-10-21 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 2985120R Medline TA: J Bacteriol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1009-14 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Culture Media DNA Transposable Elements Enzyme Repression Genes, Bacterial Isoleucine / pharmacology Leucine / pharmacology Mutation Salmonella typhimurium / enzymology*, genetics Transaminases / metabolism* Valine / pharmacology |
| Grant Support | |
ID/Acronym/Agency:
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1T32 GM-07584/GM/NIGMS NIH HHS; AI-14278/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Culture Media; 0/DNA Transposable Elements; 61-90-5/Leucine; 7004-03-7/Valine; 73-32-5/Isoleucine; EC 2.6.1.-/Transaminases; EC 2.6.1.66/valine-pyruvate transaminase |
| Comments/Corrections | |
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