Document Detail

Role of alanine-valine transaminase in Salmonella typhimurium and analysis of an avtA::Tn5 mutant.
MedLine Citation:
PMID:  6309735     Owner:  NLM     Status:  MEDLINE    
In Salmonella typhimurium, as in Escherichia coli, mutations in avtA, the gene encoding the alanine-valine transaminase (transaminase C), are silent unless they are combined with mutations involved in isoleucine-valine biosynthesis. avtA is repressed by leucine or alanine but not by valine. Transaminase C is found at reduced levels upon starvation for any one of several amino acids. We hypothesize that this is due to repression of avtA by the elevated alanine and leucine pools found in amino acid-starved cells.
C M Berg; W A Whalen; L B Archambault
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of bacteriology     Volume:  155     ISSN:  0021-9193     ISO Abbreviation:  J. Bacteriol.     Publication Date:  1983 Sep 
Date Detail:
Created Date:  1983-10-21     Completed Date:  1983-10-21     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2985120R     Medline TA:  J Bacteriol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1009-14     Citation Subset:  IM    
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MeSH Terms
Culture Media
DNA Transposable Elements
Enzyme Repression
Genes, Bacterial
Isoleucine / pharmacology
Leucine / pharmacology
Salmonella typhimurium / enzymology*,  genetics
Transaminases / metabolism*
Valine / pharmacology
Grant Support
Reg. No./Substance:
0/Culture Media; 0/DNA Transposable Elements; 61-90-5/Leucine; 7004-03-7/Valine; 73-32-5/Isoleucine; EC 2.6.1.-/Transaminases; EC transaminase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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