| Role of advanced glycation end product receptors in the pathogenesis of diabetic retinopathy. | |
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MedLine Citation:
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PMID: 20685137 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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PROBLEM: Advanced glycation end products (AGEs) and the interaction with their receptors (RAGE) play an important role in the pathogenesis of diabetic retinopathy (DR). Our study investigated whether serum soluble (s) RAGE (sRAGE) could serve as a prognostic tool for identifying the susceptibility to DR. Moreover, we examined the association between soluble forms of vascular cell adhesion molecules (sVCAM-1), nitric oxide (NO) and sRAGE levels in serum and the severity of DR. METHODS: Circulating levels of sRAGE, sVCAM-1, and NO were examined in 37 type 2 diabetic patient and 20 age-matched healthy nondiabetic subjects using ELISA. The diabetic subjects were categorized as patients without retinopathy, patients with nonproliferative DR (NPDR), and patients with proliferative DR (PDR). RESULTS: Serum sRAGE levels were significantly lower in patients with NPDR and PDR than in healthy controls and in those without retinopathy (1331.13±126.13, 934.87±66.27 vs. 1712.69±167.3, 1833.1±153.06 pg/ml, respectively, P<.05). Serum sVCAM-1 and NO were significantly higher in diabetic patients (1310.215±54.712 vs. 616.55±12.9 ng/ml and 96.432±0.864 vs. 28.78±5.88 μmol/l, respectively, P<.05) and were positively associated with the severity of DR. CONCLUSIONS: The results indicate that sRAGE is an endogenous protection factor against the occurrence of accelerated DR. |
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Authors:
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Hala O Al-Mesallamy; Lamiaa N Hammad; Tarek A El-Mamoun; Basma M Khalil |
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Publication Detail:
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Type: Journal Article Date: 2010-08-04 |
Journal Detail:
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Title: Journal of diabetes and its complications Volume: 25 ISSN: 1873-460X ISO Abbreviation: J. Diabetes Complicat. Publication Date: 2011 May-Jun |
Date Detail:
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Created Date: 2011-04-19 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9204583 Medline TA: J Diabetes Complications Country: United States |
Other Details:
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Languages: eng Pagination: 168-74 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Elsevier Inc. All rights reserved. |
Affiliation:
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Biochemistry Department, Faculty of Pharmacy, Ain-Shams University, Cairo, Egypt. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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