| Role of adrenals on development of pressure-induced myocardial hypertrophy. | |
| | |
MedLine Citation:
|
PMID: 6218759 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The effect of coarctation of the abdominal aorta (AC) and of sham operation (SO) on the development of myocardial hypertrophy was studied in three groups of male rats, i.e., a group without treatment prior to AC or SO (untreated), a group with bilateral adrenalectomy (ADX) 5-7 days before AC or SO, and a group in which the adrenal medulla was removed (MDX) 5-7 days before AC or SO. MDX resulted in functional elimination of the adrenal medulla without apparent effect on cortical function. The animals were killed 7-10 days after AC or SO. AC produced carotid blood pressure (CBP) increases of 33, 31, and 25 mmHg in the untreated, ADX, and MDX groups, respectively. Ventricular weight (HW), ventricular RNA concentration, and RNA-to-DNA ratio increased significantly after AC only in the untreated and MDX groups. In the ADX group, hypertension was followed by an increase in HW that could be detected only after normalization for body weight. It is concluded that absence of the adrenal gland significantly reduces the development of pressure-induced myocardial hypertrophy. Apparently, this is due to the absence of the adrenal cortex and not absence of the adrenal medulla. |
| | |
Authors:
|
J R Nichols; R L Clancy; N C Gonzalez |
Related Documents
:
|
1889849 - Inhibition of endopeptidase-24.15 decreases blood pressure in normotensive rats. 11004149 - Mechanisms of ventricular fibrillation induction by 60-hz alternating current in isolat... 2686089 - Observations with captopril (tensiomin) treatment in hypertensive patients (one-year pe... 15125489 - The potential role of angiotensin-converting enzyme inhibition in peripheral arterial d... 3006449 - Converting enzyme inhibition in mild and moderate essential hypertension. ii. 2580169 - Once-daily administration of captopril and hypotensive effect. 2221279 - Isoenzymes of aldehyde dehydrogenase in human lymphocytes. 1489889 - Wall thickness to lumen diameter ratios of arteries from shr and wky: comparison of pre... 16239039 - Short-term isometric exercise reduces systolic blood pressure in hypertensive adults: p... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: The American journal of physiology Volume: 244 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1983 Feb |
Date Detail:
|
Created Date: 1983-03-17 Completed Date: 1983-03-17 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: H234-8 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adrenal Glands
/
physiology Adrenalectomy* Animals Aorta, Abdominal / physiology Blood Pressure Body Water Body Weight Cardiomegaly / etiology, physiopathology* Heart / physiopathology Heart Rate Male Organ Size Rats Rats, Inbred Strains |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Tubular capacity of phosphate transport in phosphate-deprived rats: effects of nicotinamide and PTH.
Next Document: Effect of p-chlorophenylalanine on thermoregulation in unrestrained rats.