Document Detail

Role of adipose tissue for cardiovascular-renal regulation in health and disease.
MedLine Citation:
PMID:  11246814     Owner:  NLM     Status:  MEDLINE    
Obesity is associated with profound alterations of the cardiovascular system including an increase in systemic blood pressure. Several vasoactive factors, including non-esterified fatty acids, angiotensin II, prostaglandins, and nitric oxide are known to be produced by adipose tissue, and are therefore of particular interest regarding their potential role for the regulation of vascular tone and structure. In addition, central nervous system actions of the adipose tissue-derived hormone leptin may contribute to increased sympathetic nervous system activity that is typically found in obesity. Enhanced leptin-driven renal sympathetic out-flow, in combination with low atrial natriuretic peptide plasma levels possibly due to over-expression of the natriuretic peptide clearance receptor in adipocytes, may enhance sodium retention and volume expansion, both key features in the pathophysiology of obesity-associated hypertension. In this review, we discuss these and other possible contributions of adipose tissue to the regulation of cardiovascular-renal function and speculate on the role of adipose tissue for the development of obesity-associated hypertension.
S Engeli; A M Sharma
Related Documents :
1881854 - Hypertension in young patients.
17046744 - Elevation of systolic blood pressure in an animal model of olanzapine induced weight gain.
392404 - Hypertension in children.
18154474 - Use of dexmedetomidine in the pediatric intensive care unit.
20554634 - Pressure-controlled ventilation and intrabronchial pressure during one-lung ventilation.
14657064 - A calcium antagonist vs a non-calcium antagonist hypertension treatment strategy for pa...
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme     Volume:  32     ISSN:  0018-5043     ISO Abbreviation:  Horm. Metab. Res.     Publication Date:    2000 Nov-Dec
Date Detail:
Created Date:  2001-03-14     Completed Date:  2001-05-31     Revised Date:  2009-02-19    
Medline Journal Info:
Nlm Unique ID:  0177722     Medline TA:  Horm Metab Res     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  485-99     Citation Subset:  IM    
Franz-Volhard-Klinik at the Max-Delbrück-Center for Molecular Medicine, Universitätsklinikum Charité, Humboldt Universität zu Berlin, Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Adipose Tissue / physiology*
Aldosterone / physiology
Cardiovascular System / physiopathology*
Dinoprostone / physiology
Epoprostenol / physiology
Fatty Acids, Nonesterified / physiology
Hypertension / etiology,  physiopathology*
Kidney / physiopathology*
Leptin / physiology
Nitric Oxide / physiology
Obesity / complications,  physiopathology*
Renin-Angiotensin System
Reg. No./Substance:
0/Fatty Acids, Nonesterified; 0/Leptin; 10102-43-9/Nitric Oxide; 35121-78-9/Epoprostenol; 363-24-6/Dinoprostone; 52-39-1/Aldosterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  A marked upregulation of uncoupling protein 2 gene expression in adipose tissue of hyperthyroid subj...
Next Document:  Production of angiotensin II receptors type one (AT1) and type two (AT2) during the differentiation ...