| Role of adipose tissue for cardiovascular-renal regulation in health and disease. | |
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MedLine Citation:
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PMID: 11246814 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Obesity is associated with profound alterations of the cardiovascular system including an increase in systemic blood pressure. Several vasoactive factors, including non-esterified fatty acids, angiotensin II, prostaglandins, and nitric oxide are known to be produced by adipose tissue, and are therefore of particular interest regarding their potential role for the regulation of vascular tone and structure. In addition, central nervous system actions of the adipose tissue-derived hormone leptin may contribute to increased sympathetic nervous system activity that is typically found in obesity. Enhanced leptin-driven renal sympathetic out-flow, in combination with low atrial natriuretic peptide plasma levels possibly due to over-expression of the natriuretic peptide clearance receptor in adipocytes, may enhance sodium retention and volume expansion, both key features in the pathophysiology of obesity-associated hypertension. In this review, we discuss these and other possible contributions of adipose tissue to the regulation of cardiovascular-renal function and speculate on the role of adipose tissue for the development of obesity-associated hypertension. |
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Authors:
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S Engeli; A M Sharma |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme Volume: 32 ISSN: 0018-5043 ISO Abbreviation: Horm. Metab. Res. Publication Date: 2000 Nov-Dec |
Date Detail:
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Created Date: 2001-03-14 Completed Date: 2001-05-31 Revised Date: 2009-02-19 |
Medline Journal Info:
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Nlm Unique ID: 0177722 Medline TA: Horm Metab Res Country: Germany |
Other Details:
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Languages: eng Pagination: 485-99 Citation Subset: IM |
Affiliation:
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Franz-Volhard-Klinik at the Max-Delbrück-Center for Molecular Medicine, Universitätsklinikum Charité, Humboldt Universität zu Berlin, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adipose Tissue
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physiology* Aldosterone / physiology Animals Cardiovascular System / physiopathology* Dinoprostone / physiology Epoprostenol / physiology Fatty Acids, Nonesterified / physiology Humans Hypertension / etiology, physiopathology* Kidney / physiopathology* Leptin / physiology Nitric Oxide / physiology Obesity / complications, physiopathology* Renin-Angiotensin System |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids, Nonesterified; 0/Leptin; 10102-43-9/Nitric Oxide; 35121-78-9/Epoprostenol; 363-24-6/Dinoprostone; 52-39-1/Aldosterone |
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