Document Detail


Role of adipose tissue for cardiovascular-renal regulation in health and disease.
MedLine Citation:
PMID:  11246814     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Obesity is associated with profound alterations of the cardiovascular system including an increase in systemic blood pressure. Several vasoactive factors, including non-esterified fatty acids, angiotensin II, prostaglandins, and nitric oxide are known to be produced by adipose tissue, and are therefore of particular interest regarding their potential role for the regulation of vascular tone and structure. In addition, central nervous system actions of the adipose tissue-derived hormone leptin may contribute to increased sympathetic nervous system activity that is typically found in obesity. Enhanced leptin-driven renal sympathetic out-flow, in combination with low atrial natriuretic peptide plasma levels possibly due to over-expression of the natriuretic peptide clearance receptor in adipocytes, may enhance sodium retention and volume expansion, both key features in the pathophysiology of obesity-associated hypertension. In this review, we discuss these and other possible contributions of adipose tissue to the regulation of cardiovascular-renal function and speculate on the role of adipose tissue for the development of obesity-associated hypertension.
Authors:
S Engeli; A M Sharma
Related Documents :
16880104 - Obesity cardiomyopathy: is it a reality? an ultrasonic tissue characterization study.
19942864 - Relationship of low birth weight to pulsatile arterial function in asymptomatic younger...
17249484 - Blood pressure and obesity of children and adolescents association with body mass index...
17158474 - Size at birth and blood pressure in early adolescence: a prospective birth cohort study.
11703234 - The effect of cardiac output changes on end-expired volatile anaesthetic concentrations...
9594014 - Haemodynamic effects of the intravenous administration of growth hormone in anaesthetiz...
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme     Volume:  32     ISSN:  0018-5043     ISO Abbreviation:  Horm. Metab. Res.     Publication Date:    2000 Nov-Dec
Date Detail:
Created Date:  2001-03-14     Completed Date:  2001-05-31     Revised Date:  2009-02-19    
Medline Journal Info:
Nlm Unique ID:  0177722     Medline TA:  Horm Metab Res     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  485-99     Citation Subset:  IM    
Affiliation:
Franz-Volhard-Klinik at the Max-Delbrück-Center for Molecular Medicine, Universitätsklinikum Charité, Humboldt Universität zu Berlin, Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adipose Tissue / physiology*
Aldosterone / physiology
Animals
Cardiovascular System / physiopathology*
Dinoprostone / physiology
Epoprostenol / physiology
Fatty Acids, Nonesterified / physiology
Humans
Hypertension / etiology,  physiopathology*
Kidney / physiopathology*
Leptin / physiology
Nitric Oxide / physiology
Obesity / complications,  physiopathology*
Renin-Angiotensin System
Chemical
Reg. No./Substance:
0/Fatty Acids, Nonesterified; 0/Leptin; 10102-43-9/Nitric Oxide; 35121-78-9/Epoprostenol; 363-24-6/Dinoprostone; 52-39-1/Aldosterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  A marked upregulation of uncoupling protein 2 gene expression in adipose tissue of hyperthyroid subj...
Next Document:  Production of angiotensin II receptors type one (AT1) and type two (AT2) during the differentiation ...