Document Detail

Role of adequate dietary calcium intake in the prevention and management of salt-sensitive hypertension.
MedLine Citation:
PMID:  9022571     Owner:  NLM     Status:  MEDLINE    
During the past decade, a credible body of evidence has emerged supporting the concept that maintaining an adequate dietary mineral intake, specifically of calcium, magnesium, and potassium, protects against high blood pressure in humans. Observational and interventional studies in humans and extensive use of laboratory models showed that a significant portion of blood pressure variability in response to sodium chloride can be linked to the adequacy of the mineral content of the diet. This review summarizes the observational data from several large databases showing that when adults meet or exceed the recommended dietary allowances of calcium, potassium, and magnesium, the simultaneous ingestion of a diet high in sodium chloride is not associated with elevated arterial pressure. In fact, a higher sodium chloride intake in these adults is most likely associated with the lowest blood pressure in the society. This interaction between adequacy of mineral intake and protection against salt sensitivity in humans provides an important opportunity for further improving blood pressure control in our society. Educating individuals to maintain, on a daily basis, adequate intakes of calcium, potassium, and magnesium rather than limit their sodium chloride is a viable health recommendation that individuals can implement to reduce their risk of sodium chloride-induced hypertension.
D A McCarron
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  65     ISSN:  0002-9165     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  1997 Feb 
Date Detail:
Created Date:  1997-02-26     Completed Date:  1997-02-26     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  712S-716S     Citation Subset:  AIM; IM    
Division of Nephrology, Hypertension, and Clinical Pharmacology, Oregon Health Sciences University, Portland 97201, USA.
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MeSH Terms
Blood Pressure / drug effects,  physiology
Calcium / urine
Calcium, Dietary / administration & dosage*,  pharmacology,  therapeutic use
Hypertension / diet therapy*,  etiology,  prevention & control
Potassium, Dietary / administration & dosage,  pharmacology
Sodium / urine
Sodium Chloride, Dietary / adverse effects*
Reg. No./Substance:
0/Calcium, Dietary; 0/Potassium, Dietary; 0/Sodium Chloride, Dietary; 7440-23-5/Sodium; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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