| Role of adenosine for reactive hyperemia in normal and stunned porcine myocardium. | |
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MedLine Citation:
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PMID: 1415760 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The role of adenosine for reactive hyperemia in normal and stunned myocardium was examined in 16 open-chest barbiturate-anesthetized pigs. Interstitial adenosine concentration was reduced or enhanced by intracoronary infusion of adenosine deaminase or the nucleoside transport inhibitor R 75231, respectively. In normal myocardium, adenosine deaminase reduced volume of hyperemia (Doppler flowmetry) after a 30-s left anterior descending coronary artery (LAD) occlusion by 20% (6-34%; P < 0.05), whereas R 75231 increased volume of hyperemia by 15% (2-24%; P < 0.05). Adenosine deaminase reduced volume of hyperemia after a 2-min LAD occlusion by 27% (13-37%; P < 0.001), whereas R 75231 increased volume of hyperemia by 66% (53-159%; P < 0.001). Adenosine deaminase and R 75231 did not affect maximal hyperemia. Volume of hyperemia after a 2-min LAD occlusion was reduced in stunned myocardium (%systolic segment length shortening reduced by approximately 45%, ultrasonic technique) but not further altered by either adenosine deaminase or R 75231. These findings show that adenosine contributes to reactive hyperemia after 30-120 s of ischemia in normal myocardium and indicate that the reduced reactive hyperemia in stunned myocardium is due to reduced accumulation of adenosine during ischemia. |
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Authors:
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K A Kirkebøen; G Aksnes; K Lande; A Ilebekk |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The American journal of physiology Volume: 263 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1992 Oct |
Date Detail:
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Created Date: 1992-11-19 Completed Date: 1992-11-19 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: H1119-27 Citation Subset: IM |
Affiliation:
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University of Oslo, Institute for Experimental Medical Research, Ullevål Hospital, Norway. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine
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metabolism* Adenosine Deaminase / pharmacology Animals Coronary Disease / metabolism*, physiopathology Female Hemodynamics / drug effects Hyperemia / metabolism* Male Myocardial Reperfusion Injury / metabolism*, physiopathology Piperazines / pharmacology Reference Values Swine |
| Chemical | |
Reg. No./Substance:
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0/Piperazines; 120770-34-5/draflazine; 58-61-7/Adenosine; EC 3.5.4.4/Adenosine Deaminase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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