| Role of adenosine in the treatment of myocardial stunning. | |
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MedLine Citation:
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PMID: 1756136 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Adenosine is an endogenous nucleoside produced from the breakdown of adenosine triphosphate (ATP) that possesses a number of complex cellular and metabolic effects that could ameliorate postischemic contractile dysfunction (myocardial stunning). Potential mechanisms include the repletion of high-energy phosphate stores, reduced myocardial oxygen consumption, a decrease in oxygen-derived free radicals, restoration of calcium homeostasis, and an increase in regional myocardial blood flow. Experimental studies have shown that adenosine can reduce myocardial stunning with or without a concomitant increase in the total myocardial ATP stores. Adenosine may be a useful pharmacologic strategy in the prevention and treatment of ventricular dysfunction following episodes of regional or global ischemia, although further studies are needed to clarify the precise cellular mechanisms involved. |
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Authors:
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M B Forman; C E Velasco |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy Volume: 5 ISSN: 0920-3206 ISO Abbreviation: Cardiovasc Drugs Ther Publication Date: 1991 Oct |
Date Detail:
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Created Date: 1992-02-04 Completed Date: 1992-02-04 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8712220 Medline TA: Cardiovasc Drugs Ther Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 901-8 Citation Subset: IM |
Affiliation:
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Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232-2170. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine
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therapeutic use* Adenosine Triphosphate / metabolism Animals Calcium / metabolism Coronary Circulation / drug effects Coronary Disease / drug therapy* Humans Oxygen Consumption Postoperative Complications / drug therapy |
| Grant Support | |
ID/Acronym/Agency:
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R01 HL40829-01/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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56-65-5/Adenosine Triphosphate; 58-61-7/Adenosine; 7440-70-2/Calcium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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