Document Detail


Role of adenosine in the treatment of myocardial stunning.
MedLine Citation:
PMID:  1756136     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Adenosine is an endogenous nucleoside produced from the breakdown of adenosine triphosphate (ATP) that possesses a number of complex cellular and metabolic effects that could ameliorate postischemic contractile dysfunction (myocardial stunning). Potential mechanisms include the repletion of high-energy phosphate stores, reduced myocardial oxygen consumption, a decrease in oxygen-derived free radicals, restoration of calcium homeostasis, and an increase in regional myocardial blood flow. Experimental studies have shown that adenosine can reduce myocardial stunning with or without a concomitant increase in the total myocardial ATP stores. Adenosine may be a useful pharmacologic strategy in the prevention and treatment of ventricular dysfunction following episodes of regional or global ischemia, although further studies are needed to clarify the precise cellular mechanisms involved.
Authors:
M B Forman; C E Velasco
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy     Volume:  5     ISSN:  0920-3206     ISO Abbreviation:  Cardiovasc Drugs Ther     Publication Date:  1991 Oct 
Date Detail:
Created Date:  1992-02-04     Completed Date:  1992-02-04     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8712220     Medline TA:  Cardiovasc Drugs Ther     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  901-8     Citation Subset:  IM    
Affiliation:
Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232-2170.
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MeSH Terms
Descriptor/Qualifier:
Adenosine / therapeutic use*
Adenosine Triphosphate / metabolism
Animals
Calcium / metabolism
Coronary Circulation / drug effects
Coronary Disease / drug therapy*
Humans
Oxygen Consumption
Postoperative Complications / drug therapy
Grant Support
ID/Acronym/Agency:
R01 HL40829-01/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
56-65-5/Adenosine Triphosphate; 58-61-7/Adenosine; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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