Document Detail

Role of adenosine in the treatment of myocardial stunning.
MedLine Citation:
PMID:  1756136     Owner:  NLM     Status:  MEDLINE    
Adenosine is an endogenous nucleoside produced from the breakdown of adenosine triphosphate (ATP) that possesses a number of complex cellular and metabolic effects that could ameliorate postischemic contractile dysfunction (myocardial stunning). Potential mechanisms include the repletion of high-energy phosphate stores, reduced myocardial oxygen consumption, a decrease in oxygen-derived free radicals, restoration of calcium homeostasis, and an increase in regional myocardial blood flow. Experimental studies have shown that adenosine can reduce myocardial stunning with or without a concomitant increase in the total myocardial ATP stores. Adenosine may be a useful pharmacologic strategy in the prevention and treatment of ventricular dysfunction following episodes of regional or global ischemia, although further studies are needed to clarify the precise cellular mechanisms involved.
M B Forman; C E Velasco
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy     Volume:  5     ISSN:  0920-3206     ISO Abbreviation:  Cardiovasc Drugs Ther     Publication Date:  1991 Oct 
Date Detail:
Created Date:  1992-02-04     Completed Date:  1992-02-04     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8712220     Medline TA:  Cardiovasc Drugs Ther     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  901-8     Citation Subset:  IM    
Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232-2170.
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MeSH Terms
Adenosine / therapeutic use*
Adenosine Triphosphate / metabolism
Calcium / metabolism
Coronary Circulation / drug effects
Coronary Disease / drug therapy*
Oxygen Consumption
Postoperative Complications / drug therapy
Grant Support
Reg. No./Substance:
56-65-5/Adenosine Triphosphate; 58-61-7/Adenosine; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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