Document Detail

Role of adenosine in mediating the coronary vasodilative response to acute hypoxia.
MedLine Citation:
PMID:  3664545     Owner:  NLM     Status:  MEDLINE    
To test the hypothesis that adenosine is required to mediate the coronary vasodilative response to acute hypoxia haemodynamic indices, regional myocardial blood flow, and oxygen and lactate metabolism were measured in nine closed chest anaesthetised domestic swine at control, after 3-5 min of 100% nitrogen inhalation, at second control, and after 3-5 min of 100% nitrogen inhalation plus adenosine deaminase infusion in the left anterior descending coronary artery. Cardiac lymph adenosine deaminase concentration was also measured in a separate group of four animals previously reported on. Heart rate was held constant by atrial pacing during the study. Aortic mean pressure did not change. Changes in arterial and anterior interventricular vein pH, PO2, PCO2, and oxygen content were similar for each intervention. Transmural left anterior descending artery zone flow increased significantly (p less than 0.01) compared with control (1.22(0.23) ml.min-1.g-1; mean(SD)) in response to hypoxia (2.73(0.92)). Intracoronary adenosine deaminase infusion (167 nmol.s-1), however, failed to blunt the flow response to hypoxia (1.33(0.30) to 2.79(1.32); second control to hypoxia plus adenosine deaminase respectively, p less than 0.01). Mean adenosine deaminase activity (nmol.s-1) in cardiac lymph was 105(85) at the end of 10 min of intracoronary infusion (167 nmol.s-1) and 203 (148) nmol.s-1 at the end of 15 min.(ABSTRACT TRUNCATED AT 250 WORDS)
H Gewirtz; R A Olsson; A S Most
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Cardiovascular research     Volume:  21     ISSN:  0008-6363     ISO Abbreviation:  Cardiovasc. Res.     Publication Date:  1987 Feb 
Date Detail:
Created Date:  1987-12-04     Completed Date:  1987-12-04     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0077427     Medline TA:  Cardiovasc Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  81-9     Citation Subset:  IM    
Department of Medicine, Rhode Island Hospital, Providence 02902.
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MeSH Terms
Acute Disease
Adenosine / physiology*
Adenosine Deaminase / pharmacology
Anoxia / physiopathology*
Coronary Circulation / drug effects
Coronary Vessels / physiopathology*
Hemodynamics / drug effects
Lactates / metabolism
Lactic Acid
Myocardium / metabolism
Oxygen / metabolism
Vasodilation* / drug effects
Grant Support
Reg. No./Substance:
0/Lactates; 50-21-5/Lactic Acid; 58-61-7/Adenosine; 7782-44-7/Oxygen; EC Deaminase

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