Document Detail


Role of adenosine in the control of choroidal blood flow during changes in ocular perfusion pressure.
MedLine Citation:
PMID:  21697134     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: The purpose of the present study was to investigate whether the nucleoside adenosine is involved in the regulatory processes of choroidal blood flow (ChBF) during an experimental decrease in ocular perfusion pressure (OPP).
METHODS: In this randomized, double-masked, placebo-controlled, two-way crossover study, 14 subjects received either intravenous adenosine or placebo on two different study days. The suction cup method was used for a stepwise increase in intraocular pressure (IOP). Subfoveal ChBF was measured by laser Doppler flowmetry. Mean arterial pressure (MAP) and IOP were measured noninvasively. Ocular perfusion pressure was calculated as OPP = 2/3MAP - IOP.
RESULTS: Adenosine increased ChBF significantly versus placebo before application of the suction cup (P < 0.05). When the suction cup was applied, a significant decrease in OPP was observed. This effect was comparable on all study days. The decrease in OPP was paralleled by a significant decrease in ChBF (maximum between -43% and -52%) which was less pronounced than the decrease in OPP (maximum between -62% and -64%). Neither placebo nor adenosine influenced the ChBF increase during suction cup-induced changes in OPP.
CONCLUSIONS: The data of the present study confirm that the human choroid shows some regulatory capacity during a decrease in OPP. Adenosine influences basal vascular tone in the choroid but is not involved in the regulatory mechanisms during an increase in IOP. (ClinicalTrials.gov number, NCT00712764.).
Authors:
Doreen Schmidl; Guenther Weigert; Guido T Dorner; Hemma Resch; Julia Kolodjaschna; Michael Wolzt; Gerhard Garhofer; Leopold Schmetterer
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2011-07-29
Journal Detail:
Title:  Investigative ophthalmology & visual science     Volume:  52     ISSN:  1552-5783     ISO Abbreviation:  Invest. Ophthalmol. Vis. Sci.     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-08-01     Completed Date:  2011-09-30     Revised Date:  2013-01-09    
Medline Journal Info:
Nlm Unique ID:  7703701     Medline TA:  Invest Ophthalmol Vis Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  6035-9     Citation Subset:  IM    
Affiliation:
Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria.
Data Bank Information
Bank Name/Acc. No.:
ClinicalTrials.gov/NCT00712764
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MeSH Terms
Descriptor/Qualifier:
Adenosine / administration & dosage*
Adult
Choroid / blood supply*,  physiology
Cross-Over Studies
Homeostasis / drug effects,  physiology
Humans
Injections, Intravenous
Intraocular Pressure / physiology*
Male
Placebos
Regional Blood Flow / drug effects*,  physiology
Suction / methods
Vascular Resistance / drug effects,  physiology
Vasodilator Agents / administration & dosage*
Young Adult
Chemical
Reg. No./Substance:
0/Placebos; 0/Vasodilator Agents; 58-61-7/Adenosine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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