| Role of the actin cytoskeleton in tuning cellular responses to external mechanical stress. | |
| | |
MedLine Citation:
|
PMID: 19422655 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Mechanical forces are essential for tissue homeostasis. In adherent cells, cell-matrix adhesions connect the extracellular matrix (ECM) with the cytoskeleton and transmit forces in both directions. Integrin receptors and signaling molecules in cell-matrix adhesions transduce mechanical into chemical signals, thereby regulating many cellular processes. This review focuses on how cellular mechanotransduction is tuned by actin-generated cytoskeletal tension that balances external with internal mechanical forces. We point out that the cytoskeleton rapidly responds to external forces by RhoA-dependent actin assembly and contraction. This in turn induces remodeling of cell-matrix adhesions and changes in cell shape and orientation. As a consequence, a cell constantly modulates its response to new bouts of external mechanical stimulation. Changes in actin dynamics are monitored by MAL/MKL-1/MRTF-A, a co-activator of serum response factor. Recent evidence suggests that MAL is also involved in coupling mechanically induced changes in the actin cytoskeleton to gene expression. Compared with other, more rapid and transient signals evoked at the cell surface, this parallel mechanotransduction pathway is more sustained and provides spatial and temporal specificity to the response. We describe examples of genes that are regulated by mechanical stress in a manner depending on actin dynamics, among them the ECM protein, tenascin-C. |
| | |
Authors:
|
M B Asparuhova; L Gelman; M Chiquet |
Related Documents
:
|
12808045 - Calponin repeats regulate actin filament stability and formation of podosomes in smooth... 18219705 - Beta-actin-derived peptides isolated from acidic extract of rat spleen suppress tumor c... 10356985 - Characterization of the actin binding properties of the vasodilator-stimulated phosphop... 15014435 - Dynacortin contributes to cortical viscoelasticity and helps define the shape changes o... 19917165 - Low levels of endothelial progenitor cells correlate with disease duration and activity... 22745485 - Aβ1-42-rage interaction disrupts tight junctions of the blood-brain barrier via ca2+-c... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2009-04-20 |
Journal Detail:
|
Title: Scandinavian journal of medicine & science in sports Volume: 19 ISSN: 1600-0838 ISO Abbreviation: Scand J Med Sci Sports Publication Date: 2009 Aug |
Date Detail:
|
Created Date: 2009-08-27 Completed Date: 2010-01-13 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9111504 Medline TA: Scand J Med Sci Sports Country: Denmark |
Other Details:
|
Languages: eng Pagination: 490-9 Citation Subset: IM |
Affiliation:
|
Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland. maria.asparuhova@fmi.ch |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Actins
/
metabolism* Cell-Matrix Junctions Cytoskeleton / metabolism* DNA-Binding Proteins / genetics, metabolism Extracellular Matrix / metabolism Gene Expression Humans Mechanotransduction, Cellular Oncogene Proteins, Fusion / genetics, metabolism Stress, Mechanical* |
| Chemical | |
Reg. No./Substance:
|
0/Actins; 0/DNA-Binding Proteins; 0/MKL1 protein, human; 0/Oncogene Proteins, Fusion |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Dynamic postural control but not mechanical stability differs among those with and without chronic a...
Next Document: Exercise capacity in Dutch children: new reference values for the Bruce treadmill protocol.