Document Detail

Role of Y chromosome of hypertensive parent in determination of blood pressure in normotensive offspring.
MedLine Citation:
PMID:  9476568     Owner:  NLM     Status:  MEDLINE    
We investigated whether the sex of hypertensive parents mediates determination of blood pressure in their normotensive offspring. We analyzed medical checkup data from 7279 Japanese university students. Six hundred and forty-one students had one hypertensive parent with or without hypertensive grandparents, and 609 of these were available for the present analysis. Blood pressure levels in the students with one hypertensive parent were within the normotensive range; however, the blood pressure levels were higher than those in students without hypertensive relatives, and lower than those in students with two hypertensive parents. In the students with one hypertensive parent, systolic blood pressure levels were significantly higher in the male than in the female students. However, the sex of the hypertensive parent did not affect the blood pressure values of their offspring. Multivariate analyses revealed that body mass index was an independent predictor of systolic blood pressure solely in male students with a hypertensive father, but not in male students with a hypertensive mother. In female students with one hypertensive parent, body mass index was irrelevant to the determination of blood pressure. These findings suggest that different mechanisms determine blood pressure in the offspring of hypertensive parents, and that blood pressure determination mediated by body mass index in male students is linked to hypertensive Y chromosome.
Y Uehara; W S Shin; T Watanabe; T Osanai; M Miyazaki; H Kanase; K Sugano; T Toyo-Oka
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Heart and vessels     Volume:  Suppl 12     ISSN:  0910-8327     ISO Abbreviation:  Heart Vessels     Publication Date:  1997  
Date Detail:
Created Date:  1998-04-07     Completed Date:  1998-04-07     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8511258     Medline TA:  Heart Vessels     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  156-9     Citation Subset:  IM    
Health Service Center, University of Tokyo, Japan.
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MeSH Terms
Body Mass Index
Hypertension / genetics*
Multivariate Analysis
Sex Characteristics*
Sex Factors
Y Chromosome*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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