| The Role of Waixenicin A as Transient Receptor Potential Melastatin 7 Blocker. | |
| | |
MedLine Citation:
|
PMID: 22901271 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Transient Receptor Potential Melastatin 7 (TRPM7) plays a role in a number of physiological and pharmacological functions in variety of cells. The aim of this study was to clarify the role for TRPM7 channels and the effect of waixenicin A on the pacemaking activity of interstitial cells of Cajal (ICCs) and on the cell viability of the human gastric and breast adenocarcinoma cell lines, AGS and MCF-7, respectively. Waixenicin A decreased the amplitude of pacemaker potentials in cultured ICC clusters and inhibited TRPM7 currents, but had no effect on Ca(2+) -activated Cl(-) conductance (ANO1). Furthermore, waixenicin A was found to inhibit the growth and survival of AGS and MCF-7 cells. These findings indicate that TRPM7 channel modulates intestinal motility and regulates the pathophysiology of human gastric and breast adenocarcinoma cells. These findings suggest that TRPM7 channel be considered a potential target for the treatment of gut motor disorders and gastric and breast cancer. |
| | |
Authors:
|
Byung Joo Kim; Joo Hyun Nam; Young Kyu Kwon; Insuk So; Seon Jeong Kim |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-8-18 |
Journal Detail:
|
Title: Basic & clinical pharmacology & toxicology Volume: - ISSN: 1742-7843 ISO Abbreviation: Basic Clin. Pharmacol. Toxicol. Publication Date: 2012 Aug |
Date Detail:
|
Created Date: 2012-8-20 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101208422 Medline TA: Basic Clin Pharmacol Toxicol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
© 2012 The Authors Basic & Clinical Pharmacology & Toxicology © 2012 Nordic Pharmacological Society. |
Affiliation:
|
Division of Longevity and Biofunctional Medicine, Pusan National University School of Korean Medicine, Yangsan, Republic of Korea. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Prospects and challenges of induced pluripotent stem cells as a source of hematopoietic stem cells.
Next Document: DNA Base Pair Stacks with High Electric Conductance: A Systematic Structural Search.