| The Role of Vitamin D in Dyslipidemia and Cardiovascular Disease. | |
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MedLine Citation:
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PMID: 21418036 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Dyslipidemia and vascular calcification are important predictors of cardiovascular disease (CVD). Vitamin D may have an influence on these two CVD risk markers. We performed a systematic review on vitamin D, dyslipidemia, statins, vascular calcification and CVD. The vast majority of intervention studies did not show an effect of vitamin D on serum cholesterol levels. There is however evidence for a triglyceride-lowering effect of vitamin D which primarily comes from studies with chronic kidney disease patients, a group with elevated triglyceride levels. The previously presumed influence of statins on circulating 25-hydroxyvitamin D levels and on cellular vitamin D actions remains obscure. Experimental studies on vascular calcification and CVD suggest a biphasic effect of vitamin D with harmful effects at both low and high vitamin D levels. Epidemiological studies on vitamin D and vascular calcification are inconsistent at present, but are probably biased by confounding. Prospective cohort studies consistently indicate an enhanced multivariable-adjusted CVD mortality risk when circulating 25-hydroxyvitamin D levels are below 25 nmol/l. Adequately designed randomised controlled trials investigating the dose-response effect of vitamin D on different CVD outcome parameters are now warranted. |
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Authors:
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Armin Zittermann; Jan F Gummert; Jochen Börgermann |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-3-22 |
Journal Detail:
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Title: Current pharmaceutical design Volume: - ISSN: 1873-4286 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-3-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9602487 Medline TA: Curr Pharm Des Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Clinic for Thoracic and Cardiovascular Surgery Heart Center North Rhine - Westphalia Ruhr University Bochum Georgstraße 11 32545 Bad Oeynhausen, Germany. azittermann@hdz-nrw.de. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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