Document Detail


Role of vitamin C and E supplementation on IL-6 in response to training.
MedLine Citation:
PMID:  22207723     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Vitamin C and E supplementation has been shown to attenuate the acute exercise-induced increase in plasma interleukin-6 (IL-6) concentration. Here, we studied the effect of antioxidant vitamins on the regulation of IL-6 expression in muscle and the circulation in response to acute exercise before and after high-intensity endurance exercise training. Twenty-one young healthy men were allocated into either a vitamin (VT; vitamin C and E, n = 11) or a placebo (PL, n = 10) group. A 1-h acute bicycling exercise trial at 65% of maximal power output was performed before and after 12 wk of progressive endurance exercise training. In response to training, the acute exercise-induced IL-6 response was attenuated in PL (P < 0.02), but not in VT (P = 0.82). However, no clear difference between groups was observed (group × training: P = 0.13). Endurance exercise training also attenuated the acute exercise-induced increase in muscle-IL-6 mRNA in both groups. Oxidative stress, assessed by plasma protein carbonyls concentration, was overall higher in the VT compared with the PL group (group effect: P < 0.005). This was accompanied by a general increase in skeletal muscle mRNA expression of antioxidative enzymes, including catalase, copper-zinc superoxide dismutase, and glutathione peroxidase 1 mRNA expression in the VT group. However, skeletal muscle protein content of catalase, copper-zinc superoxide dismutase, or glutathione peroxidase 1 was not affected by training or supplementation. In conclusion, our results indicate that, although vitamin C and E supplementation may attenuate exercise-induced increases in plasma IL-6 there is no clear additive effect when combined with endurance training.
Authors:
Christina Yfanti; Christian P Fischer; Søren Nielsen; Thorbjörn Akerström; Anders R Nielsen; Aristidis S Veskoukis; Demetrios Kouretas; Jens Lykkesfeldt; Henriette Pilegaard; Bente K Pedersen
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2011-12-29
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  112     ISSN:  1522-1601     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-03-16     Completed Date:  2012-09-13     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  990-1000     Citation Subset:  IM    
Affiliation:
The Centre of Inflammation and Metabolism, Department of Infectious Diseases, and Copenhagen Muscle Research Centre, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark. christinayfanti@inflammation-metabolism.dk
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MeSH Terms
Descriptor/Qualifier:
Adult
Antioxidants / pharmacology
Ascorbic Acid / administration & dosage*,  blood
Body Mass Index
Catalase / metabolism
Dietary Supplements
Double-Blind Method
Exercise / physiology*
Glutathione Peroxidase / metabolism
Humans
Hydrocortisone / blood,  metabolism
Interleukin 1 Receptor Antagonist Protein / blood,  metabolism
Interleukin-6 / blood,  metabolism*
Male
Muscle Proteins / metabolism
Muscle, Skeletal / drug effects,  metabolism,  physiology
Oxidative Stress / drug effects,  physiology
Physical Endurance / drug effects*,  physiology*
Superoxide Dismutase / metabolism
Vitamin E / administration & dosage*,  blood
Chemical
Reg. No./Substance:
0/Antioxidants; 0/Interleukin 1 Receptor Antagonist Protein; 0/Interleukin-6; 0/Muscle Proteins; 1406-18-4/Vitamin E; 50-23-7/Hydrocortisone; 50-81-7/Ascorbic Acid; EC 1.11.1.-/glutathione peroxidase GPX1; EC 1.11.1.6/Catalase; EC 1.11.1.9/Glutathione Peroxidase; EC 1.15.1.1/Superoxide Dismutase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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