Document Detail


The role of vascular endothelial growth factors and fibroblast growth factors in angiogenesis during otitis media.
MedLine Citation:
PMID:  22104377     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The middle ear response to otitis media includes transformation and hyperplasia of the mucosal epithelium and subepithelial connective tissue. Significant neovascularization is also noted, which occurs both to support the hypertrophied mucosa and to mediate the increased trafficking of leukocytes. We investigated the role of two known potent angiogenic growth factor families, the fibroblast growth factors (FGFs) and vascular endothelial growth factors (VEGFs), in middle ear mucosal angiogenesis. DNA microarrays were used to evaluate the expression of FGFs and VEGFs, as well as their receptors and unique signaling proteins, in the middle ears of mice undergoing a complete course of acute bacterial otitis media. In addition, a member of each family was introduced to the middle ear submucosal compartment of the normal middle ears of guinea pigs, by a continuous-release osmotic minipump system over 1 week. During the course of bacterial otitis media, a significant regulation of a number of genes important for angiogenesis was identified. Histologic evaluation of middle ear mucosa following micropump infusion of both FGF1 and VEGF-A showed significant angiogenesis at the site of infusion in comparison to control saline infusion. These results support a role for FGFs and VEGFs in the neovascularization of the middle ear mucosa during otitis media, and offer a potential avenue for therapeutic intervention.
Authors:
Jacob Husseman; Sean D Palacios; Alexander Z Rivkin; Heinz Oehl; Allen F Ryan
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2011-11-19
Journal Detail:
Title:  Audiology & neuro-otology     Volume:  17     ISSN:  1421-9700     ISO Abbreviation:  Audiol. Neurootol.     Publication Date:  2012  
Date Detail:
Created Date:  2012-04-04     Completed Date:  2012-08-01     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  9606930     Medline TA:  Audiol Neurootol     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  148-54     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 S. Karger AG, Basel.
Affiliation:
Department of Surgery/Otolaryngology, University of California, San Diego, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Ear, Middle / metabolism*,  pathology
Fibroblast Growth Factors / metabolism*
Guinea Pigs
Mice
Neovascularization, Pathologic / metabolism*,  pathology
Otitis Media / metabolism*,  microbiology,  pathology
Vascular Endothelial Growth Factor A / metabolism*
Grant Support
ID/Acronym/Agency:
DC000028/DC/NIDCD NIH HHS; DC000129/DC/NIDCD NIH HHS; DC006279/DC/NIDCD NIH HHS; I01 BX001205/BX/BLRD VA; R01 DC000129/DC/NIDCD NIH HHS; T32 DC000028/DC/NIDCD NIH HHS
Chemical
Reg. No./Substance:
0/Vascular Endothelial Growth Factor A; 62031-54-3/Fibroblast Growth Factors
Comments/Corrections

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