Document Detail


Role of Ureaplasma urealyticum and other pathogens in the development of chronic lung disease of prematurity.
MedLine Citation:
PMID:  2845345     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A prospective cohort study enrolling 107 infants weighing less than 1250 g was conducted between September 1, 1986, and November 15, 1987 in order to determine the role of microorganisms on the development of chronic lung disease (CLD). Ureaplasma urealyticum was isolated significantly more frequently from gastric aspirates and nasopharyngeal or endotracheal aspirates from 43 infants developing CLD than from 56 who did not (51% vs. 16%; P less than 0.005). Infants developing CLD, defined by radiographic and blood gas abnormalities, were significantly younger (26 vs. 29 weeks; P less than 0.0001), weighed significantly less (830 vs. 1050 g; P less than 0.0001) and required more ventilatory support (37 vs. 10 were being ventilated and 42 vs. 26 received oxygen supplementation on Day 7) compared with those who did not develop CLD. Viruses were isolated in association with U. urealyticum in two infants developing CLD and in one infant who did not develop CLD. Mycoplasma hominis was isolated from three infants who were colonized with U. urealyticum and developed CLD. Chlamydia trachomatis was not recovered from any patients. From a discriminant analysis it was found that U. urealyticum contributed to the development of CLD along with the effect of ventilatory support, gestational age and severity of initial respiratory disease. The effect of interventions directed against U. urealyticum on the development of CLD deserves further study.
Authors:
E E Wang; H Frayha; J Watts; O Hammerberg; M A Chernesky; J B Mahony; G H Cassell
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Pediatric infectious disease journal     Volume:  7     ISSN:  0891-3668     ISO Abbreviation:  Pediatr. Infect. Dis. J.     Publication Date:  1988 Aug 
Date Detail:
Created Date:  1988-11-07     Completed Date:  1988-11-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8701858     Medline TA:  Pediatr Infect Dis J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  547-51     Citation Subset:  IM    
Affiliation:
Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada.
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MeSH Terms
Descriptor/Qualifier:
Birth Weight
Bronchopulmonary Dysplasia / microbiology*
Chlamydia trachomatis / isolation & purification
Female
Gestational Age
Humans
Infant, Newborn
Infant, Premature, Diseases / microbiology*
Male
Mycoplasmatales Infections / microbiology*
Nasopharynx / microbiology
Respiratory Syncytial Viruses / isolation & purification
Respirovirus / isolation & purification
Risk Factors
Trachea / microbiology
Ureaplasma / isolation & purification

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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