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Role of Transition Metals in UV-B Induced Damage to Bacteria.
MedLine Citation:
PMID:  23360113     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The purpose of this study was to explore the possible link between metals and UV-B induced damage in bacteria. The effect of growth in the presence of enhanced concentrations of different transition metals (Co, Cu, Fe, Mn and Zn) on the UV-B sensitivity of a set of bacterial isolates was explored in terms of survival, activity and oxidative stress biomarkers (ROS generation, damage to DNA, lipid and proteins, and activity of antioxidant enzymes). Metal amendment, particularly Fe, Cu and Mn, enhanced bacterial inactivation during irradiation by up to 35.8%. Amendment with Fe increased ROS generation during irradiation by 1.2%-13.3%, DNA damage by 10.8%-37.4% and lipid oxidative damage by 9.6%-68.7%. Lipid damage during irradiation also increased after incubation with Cu and Co by up to 66.8% and 56.5%, respectively. Mn amendment decreased protein carbonylation during irradiation by up to 44.2%. These results suggest a role of Fe, Co, Cu and Mn in UV-B induced bacterial inactivation and the importance of metal homeostasis to limit the detrimental effects of ROS generated during irradiation. © 2013 Wiley Periodicals, Inc. Photochemistry and Photobiology © 2013 The American Society of Photobiology.
Authors:
Ana L Santos; Newton C M Gomes; Isabel Henriques; Adelaide Almeida; António Correia; Angela Cunha
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-29
Journal Detail:
Title:  Photochemistry and photobiology     Volume:  -     ISSN:  1751-1097     ISO Abbreviation:  Photochem. Photobiol.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376425     Medline TA:  Photochem Photobiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2013 Wiley Periodicals, Inc. Photochemistry and Photobiology © 2013 The American Society of Photobiology.
Affiliation:
Dapartment of Biology & CESAM, University of Aveiro, Campus Universitário de Santiago, 3810-193, Aveiro, Portugal.
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