| Role of transcranial Doppler ultrasonography in cerebrovascular disease. | |
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MedLine Citation:
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PMID: 19705994 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Transcranial Doppler ultrasonography (TCD) is the only non-invasive examination that provides a reliable evaluation of intracranial blood flow patterns in real-time, adding physiological information to the anatomical information obtained from other neuroimaging modalities. TCD is relatively cheap, can be performed bedside, and allows monitoring both in acute emergency settings as well as for prolonged periods with a high temporal resolution making it ideal for studying dynamic cerebrovascular responses. Extended applications of transcranial Doppler in enhancing intravenous thrombolysis in acute stroke, emboli monitoring, right-to-left shunt detection and vasomotor reactivity provide important information about the pathophysiology of cerebrovascular ischemia. In acute cerebral ischemia, TCD is capable of providing rapid information about the hemodynamic status of the cerebral circulation, monitoring recanalization in real-time with a potential for enhancing tissue plasminogen activator (TPA) induced thrombolysis. Advanced applications of TCD make it an important and valuable tool for evaluating stroke mechanisms, plan and monitor treatment and determine prognosis. TCD has an established clinical value in the diagnostic workup of stroke patients and is suggested as essential components of a comprehensive stroke center. We have reviewed various recent patents in addition to the diagnostic, therapeutic, as well as, prognostic applications of TCD in patients with cerebrovascular disease. |
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Authors:
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Leonard L L Yeo; Vijay K Sharma |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Recent patents on CNS drug discovery Volume: 5 ISSN: 2212-3954 ISO Abbreviation: Recent Pat CNS Drug Discov Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2009-12-17 Completed Date: 2010-03-01 Revised Date: 2011-11-10 |
Medline Journal Info:
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Nlm Unique ID: 101265656 Medline TA: Recent Pat CNS Drug Discov Country: United Arab Emirates |
Other Details:
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Languages: eng Pagination: 1-13 Citation Subset: IM |
Affiliation:
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Division of Neurology, National University Hospital, Singapore. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cerebrovascular Circulation
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drug effects,
physiology Cerebrovascular Disorders / drug therapy, pathology, ultrasonography* Hemodynamics / drug effects, physiology Humans Tissue Plasminogen Activator / pharmacology, therapeutic use Ultrasonography, Doppler, Transcranial / methods* |
| Chemical | |
Reg. No./Substance:
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EC 3.4.21.68/Tissue Plasminogen Activator |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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