| The role of topiramate and other anticonvulsants in the treatment of alcohol dependence: a clinical review. | |
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MedLine Citation:
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PMID: 20201814 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Alcohol dependence is a major health problem worldwide. Various pharmacological agents have been used in the management of alcohol dependence. This review looks at the role of topiramate and other anticonvulsants in the management of alcohol dependence. Topiramate is the most widely used anticonvulsant in the treatment of alcohol dependence. The literature on topiramate is reviewed and critically analyzed, along with its proposed mechanism of action in alcohol dependence. A review of data available on other anticonvulsants like carbamazepine, oxcarbazepine, sodium valproate, gabapentin and levetiracetam are presented and their potential in the treatment of alcohol dependence is considered, together with future research directions. |
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Authors:
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Avinash De Sousa |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: CNS & neurological disorders drug targets Volume: 9 ISSN: 1996-3181 ISO Abbreviation: CNS Neurol Disord Drug Targets Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-03-05 Completed Date: 2010-06-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101269155 Medline TA: CNS Neurol Disord Drug Targets Country: United Arab Emirates |
Other Details:
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Languages: eng Pagination: 45-9 Citation Subset: IM |
Affiliation:
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Carmel, 18, St. Francis Avenue, Off S.V. Road, Santacruz (West), Mumbai-400054, Maharashtra, India. avinashdes999@yahoo.co.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alcohol-Induced Disorders, Nervous System
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drug therapy*,
metabolism,
physiopathology Alcoholism / drug therapy*, metabolism, physiopathology Anticonvulsants / pharmacology*, therapeutic use* Brain / drug effects, metabolism, physiopathology Brain Chemistry / drug effects, physiology Fructose / analogs & derivatives*, pharmacology, therapeutic use Humans Mood Disorders / complications, drug therapy, physiopathology Substance Withdrawal Syndrome / drug therapy, physiopathology, prevention & control |
| Chemical | |
Reg. No./Substance:
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0/Anticonvulsants; 30237-26-4/Fructose; 97240-79-4/topiramate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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