Document Detail


Role of Tissue Factor in Atherothrombosis.
MedLine Citation:
PMID:  22886473     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Atherothrombosis describes the acute thrombotic event that occurs after rupture of an atherosclerotic plaque. It often leads to arterial occlusion and subsequent clinical manifestations of myocardial infarction, stroke, and sudden death. Tissue factor (TF) is the receptor for plasma factor VIIa (FVIIa) and, once formed, the TF:FVIIa complex activates the coagulation cascade. TF is present at high levels within atherosclerotic lesions and is also present on circulating monocytes and microparticles in patients with advanced cardiovascular disease (CVD). Formation of the TF:FVIIa complex plays a central role in atherothrombosis. This review will describe the cellular sources of TF, the potential of TF-positive microparticles as a biomarker of thrombotic risk, and current pharmacologic approaches to inhibit TF as a therapeutic intervention in patients with CVD.
Authors:
A Phillip Owens; Nigel Mackman
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-11
Journal Detail:
Title:  Current atherosclerosis reports     Volume:  -     ISSN:  1534-6242     ISO Abbreviation:  Curr Atheroscler Rep     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100897685     Medline TA:  Curr Atheroscler Rep     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Medicine, Division of Hematology and Oncology, McAllister Heart Institute, University of North Carolina at Chapel Hill, 98 Manning Drive Campus Box 7035, Chapel Hill, NC, 27599, USA, apowens3@email.unc.edu.
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