Document Detail


Role of TSG101 in cancer.
MedLine Citation:
PMID:  23276921     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The tumor susceptibility gene 101 (TSG101) encodes a multidomain protein that contains a UEV (ubiquitin e2 variant) domain at is N-terminus and a putative DNA-binding motif at its C-terminus. In addition to being a bona fide component of the ESCRT (endosomal sorting complexes required for transport) complex 1 and playing a critical role in endosomal sorting and trafficking, TSG101 has also been implicated in an array of cellular functions including, cytokinesis, protein ubiquitination, transcriptional regulation, cell cycle and proliferation, as well as viral budding. The major focus of this article is on the role of TSG101 in tumorigenesis.
Authors:
Yun Jiang; Yu Ou; Xiaodong Cheng
Publication Detail:
Type:  Journal Article; Review     Date:  2013-01-01
Journal Detail:
Title:  Frontiers in bioscience (Landmark edition)     Volume:  18     ISSN:  1093-4715     ISO Abbreviation:  Front Biosci (Landmark Ed)     Publication Date:  2013  
Date Detail:
Created Date:  2013-01-01     Completed Date:  2013-06-12     Revised Date:  2013-07-29    
Medline Journal Info:
Nlm Unique ID:  101612996     Medline TA:  Front Biosci (Landmark Ed)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  279-88     Citation Subset:  IM    
Affiliation:
Department of Pharmacology and Toxicology, The University of Texas Medical Branch, 301 University Boulevard, Galveston, Texas 77555-0615, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Breast Neoplasms / genetics
DNA-Binding Proteins / chemistry,  physiology*
Endosomal Sorting Complexes Required for Transport / chemistry,  physiology*
Female
Humans
Lung Neoplasms / genetics
Male
Mice
Ovarian Neoplasms / genetics
Prostatic Neoplasms / genetics
Transcription Factors / chemistry,  physiology*
Chemical
Reg. No./Substance:
0/DNA-Binding Proteins; 0/Endosomal Sorting Complexes Required for Transport; 0/Transcription Factors; 0/Tsg101 protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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