Document Detail

Role of TRPM8 and TRPA1 for cold allodynia in patients with cold injury.
MedLine Citation:
PMID:  18440147     Owner:  NLM     Status:  MEDLINE    
Local cold injury often induces hypersensitivity to cold and cold allodynia. Sensitisation of TRPM8 or TRPA1 could be the underlying mechanisms. This was evaluated by psychophysics and axon-reflex-flare induction following topical menthol and cinnamaldehyde application in cold injury patients and healthy subjects. The patients had no signs of neuropathy except cold allodynia. We applied 20% cinnamaldehyde and 40% menthol solutions in the cold-allodynic area of the patients and in a corresponding area in healthy subjects and obtained sensory ratings during application. Thermotesting and Laser Doppler Imaging were performed before and after exposure to the compounds. Menthol did not induce axon-reflex-erythema in patients or in controls. After menthol cold pain threshold was decreased in healthy subjects; however, no further sensitisation was observed in the patients moreover in some patients an amelioration of their cold allodynia was observed. Cinnamaldehyde-induced pain sensation did not differ between patients and controls. Heat pain thresholds following cinnamaldehyde were lowered to a similar extent in patients and controls (43-39.8 and 44-39 degrees C) and also the axon-reflex-flare responses were comparable. No evidence for sensitisation of responses to TRPM8 or TRPA1-stimulation was found in patients with cold injury-induced cold allodynia. The lack of TRPM8 induced axon-reflex indicates that also de-novo expression of TRPM8 on mechano-insensitive C-nociceptors does not underlie cold allodynia in these patients. We conclude from these data that the mechanisms for the induction of cold allodynia in the patients with cold injury are independent of TRPM8 or TRPA1 and differ therefore from neuropathic pain patients.
Barbara Namer; Inge Petter Kleggetveit; Hermann Handwerker; Martin Schmelz; Ellen Jorum
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2008-04-25
Journal Detail:
Title:  Pain     Volume:  139     ISSN:  1872-6623     ISO Abbreviation:  Pain     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-09-22     Completed Date:  2009-04-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7508686     Medline TA:  Pain     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  63-72     Citation Subset:  IM    
Department of Physiology and Pathophysiology, University of Erlangen, Universitätsstr. 17, 91054 Erlangen, Germany.
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MeSH Terms
Acrolein / analogs & derivatives,  toxicity
Afferent Pathways / drug effects,  metabolism,  physiopathology
Calcium Channels / physiology*
Cold Temperature / adverse effects*
Cross-Over Studies
Double-Blind Method
Menthol / toxicity
Nerve Fibers, Unmyelinated / drug effects,  metabolism,  pathology
Nerve Tissue Proteins / physiology*
Nociceptors / drug effects,  metabolism,  pathology
Pain / chemically induced,  metabolism*,  physiopathology*
Pain Threshold / drug effects,  physiology
TRPM Cation Channels / biosynthesis,  genetics,  physiology*
Temperature Sense / drug effects,  physiology
Transient Receptor Potential Channels / physiology*
Reg. No./Substance:
0/Calcium Channels; 0/Nerve Tissue Proteins; 0/TRPA1 protein, human; 0/TRPM Cation Channels; 0/TRPM8 protein, human; 0/Transient Receptor Potential Channels; 104-55-2/cinnamic aldehyde; 107-02-8/Acrolein; 1490-04-6/Menthol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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