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Role of TNF-α polymorphism -308 in neurosensory irritation.
MedLine Citation:
PMID:  20646084     Owner:  NLM     Status:  In-Data-Review    
Neurosensory cutaneous discomfort in response to topical products is common, yet the relationship between symptoms such as stinging and visible irritation is currently unclear. The presence of a polymorphism at position -308 on the TNF-α gene has been associated with skin irritation, i.e., erythema, dryness. Individuals with a G to A transition (AA/GA genotypes) have a lower threshold to experimentally induced irritation than those with the wild type (G allele, GG genotype). We investigated the effect of this polymorphism on neurosensory irritation (NSI). DNA genotyping was used to determine the allele type amongst a population of health care workers. The neurosensory response to lactic acid and water on the nasolabial folds and hands was assessed using a quantitative lactic acid sting test. Both genotypes had a more intense response to lactic acid compared with water on the face. The AA/GA genotypes had directionally higher scores from lactic acid (P = 0.1) and significantly higher stinging intensities from water (P = 0.001) on the face. For the hands, stinging intensities were higher for lactic acid and water amongst the AA/GA genotypes (P = 0.03 and 0.006 respectively). NSI to lactic acid was significantly higher on the face than on the hands (P < 0.05). Our findings indicate that subjects with the A transition at position -308 on the TNF-α gene experience more intense NSI with common ingredients, i.e., lactic acid and water, than those with the wild type. TNF-α polymorphism -308 may account for some of the inter-individual variability in response to skin care practices.
J A Davis; M O Visscher; R R Wickett; S B Hoath
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of cosmetic science     Volume:  33     ISSN:  1468-2494     ISO Abbreviation:  Int J Cosmet Sci     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-03-04     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8007161     Medline TA:  Int J Cosmet Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  105-12     Citation Subset:  IM    
Copyright Information:
© 2010 The Authors. Journal compilation. © 2010 Society of Cosmetic Scientists and the Société Française de Cosmétologie.
College of Pharmacy Department of Pediatrics, Division of Neonatology and Pulmonary Biology, Skin Sciences Institute, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH, U.S.A.
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