Document Detail


The Role of TGF-β in Polycystic Ovary Syndrome.
MedLine Citation:
PMID:  23585338     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Polycystic ovary syndrome (PCOS) is a common endocrine disorder characterized by chronic oligoanovulation and hyperandrogenism and associated with insulin resistance, type 2 diabetes, and cardiovascular risk. In recent years, genetic studies have linked PCOS to a dinucleotide marker D19S884 in the fibrillin 3 gene. Fibrillins make up the major component of microfibrils in the extracellular matrix (ECM) and interact with molecules in the ECM to regulate transforming growth factor β (TGF-β) signaling. Therefore, variations in fibrillin 3 and subsequent dysregulation of TGF-β may contribute to the pathogenesis of PCOS. Here, we review the evidence from genetic studies supporting the role of TGF-β in PCOS and describe how TGF-β dysregulation may contribute to (1) the fetal origins of PCOS, (2) reproductive abnormalities in PCOS, and (3) cardiovascular and metabolic abnormalities in PCOS.
Authors:
Nazia Raja-Khan; Margrit Urbanek; Raymond J Rodgers; Richard S Legro
Related Documents :
25370548 - Unilateral superior vena cava syndrome.
25192398 - Treating turner syndrome: a patient's perspective.
24002408 - Hirsutism - from diagnosis to use of antiandrogens.
25003228 - Oral contraceptives in polycystic ovary syndrome.
11821198 - Managing anterior capsule contraction by mechanical widening with vitrector-cut capsulo...
24365248 - A case of susac syndrome with cervical spinal cord involvement on mri.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-4-12
Journal Detail:
Title:  Reproductive sciences (Thousand Oaks, Calif.)     Volume:  -     ISSN:  1933-7205     ISO Abbreviation:  Reprod Sci     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-4-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101291249     Medline TA:  Reprod Sci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
1Division of Endocrinology, Diabetes, and Metabolism, Pennsylvania State University College of Medicine, M.S. Hershey Medical Center, Hershey, PA, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Coagulation and fibrinolytic indices during the first trimester of pregnancy in women with polycysti...
Next Document:  Changes in neuroactive steroid concentrations after preterm delivery in the Guinea pig.