Document Detail

Role of T2* magnetic resonance in monitoring iron chelation therapy.
MedLine Citation:
PMID:  19907152     Owner:  NLM     Status:  MEDLINE    
The monitoring of chelation therapy is a very important part of the management of transfusion-dependent patients. Classical methods of monitoring iron loading are either unreliable or unable to detect important myocardial siderosis which can predispose to the development of cardiac complications such as heart failure. The development of the T2* technique using cardiovascular magnetic resonance has allowed clinicians to have a reliable method for measuring cardiac iron to guide chelation therapy. T2* can identify early those patients who are at risk of developing cardiac complications, enabling personalised, tailored therapy to avoid potential problems.
John-Paul Carpenter; Dudley J Pennell
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-11-10
Journal Detail:
Title:  Acta haematologica     Volume:  122     ISSN:  1421-9662     ISO Abbreviation:  Acta Haematol.     Publication Date:  2009  
Date Detail:
Created Date:  2009-11-12     Completed Date:  2009-11-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0141053     Medline TA:  Acta Haematol     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  146-54     Citation Subset:  IM    
Copyright Information:
Copyright 2009 S. Karger AG, Basel.
Cardiovascular Magnetic Resonance Unit, Royal Brompton Hospital, London, UK.
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MeSH Terms
Clinical Trials as Topic
Ferritins / blood
Iron / metabolism
Iron Chelating Agents / therapeutic use*
Liver / metabolism
Magnetic Resonance Imaging / methods*
Monitoring, Physiologic / methods*
Myocardium / metabolism
Reproducibility of Results
Thalassemia / drug therapy*,  metabolism
Reg. No./Substance:
0/Iron Chelating Agents; 7439-89-6/Iron; 9007-73-2/Ferritins

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