Document Detail

Role of T-cells in diabetic pregnancy and macrosomia.
MedLine Citation:
PMID:  18341209     Owner:  NLM     Status:  MEDLINE    
A number of studies have recently addressed the correlationship between diabetic pregnancy/macrosomia and differentiation of T-cells into Th1 and Th2 subsets. Diabetic pregnancy has been found to be associated with a decreased Th1 phenotype and IL-4 mRNA expression. In macrosomic offspring, high expression of IL-2 and IFN-gamma mRNA, but not of Th2 cytokines is observed, indicating that the Th1 phenotype is upregulated during macrosomia. T-cells of gestational diabetic rats and their macrosomic offspring seem to present a defect in signal transduction. Indeed, the recruitment of free intracellular calcium concentrations from intracellular pool in T-cells of these animals is altered. The phenotype of regulatory T-cells (T-Reg) is upregulated in diabetic pregnancy and their infants. T-cells in diabetic pregnancy and macrosomic obese offspring are in vivo activated. Adipokines and peroxisome proliferator-activated receptor-alpha (PPARalpha) also seem to modulate the pro-inflammatory cytokines in these pathologies. Hence, activation of the immune system might be considered as one of the regulatory pathways including metabolic abnormalities in these two pathologies.
Naim Akhtar Khan
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Indian journal of biochemistry & biophysics     Volume:  44     ISSN:  0301-1208     ISO Abbreviation:  Indian J. Biochem. Biophys.     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2008-03-17     Completed Date:  2008-04-08     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0310774     Medline TA:  Indian J Biochem Biophys     Country:  India    
Other Details:
Languages:  eng     Pagination:  344-9     Citation Subset:  IM    
UPRES EA 4183 Lipides & Signalisation Cellulaire, Université de Bourgogne, Faculté des Sciences de la vie, 6, Boulevard Gabriel, 21000 Dijon, France.
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MeSH Terms
Diabetes, Gestational / immunology*
Fetal Macrosomia / immunology*
Immunity, Innate / immunology*
Models, Immunological*
T-Lymphocytes, Regulatory / immunology*
Th1 Cells / immunology*

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