| The role of T-helper cells in atherosclerosis. | |
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MedLine Citation:
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PMID: 21054264 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Atherosclerosis is rapidly gaining recognition as an inflammatory disease showing contribution from innate and adaptive immunity pathways towards disease initiation and progression. Components of adaptive immunity especially T cells, are shown to be involved in atherogenesis and subsets of T cells are known to drive/ dampen inflammatory processes in atherosclerosis. However, the regulatory balance between the T cell subsets remains unclear. In this review, we summarize the role of T helper cells Th1, 2, 3 and 17, and regulatory cells Treg in atherosclerosis by studying the cytokines involved in Th cell functioning. We further examine the diverse roles of T helper cells for regulating the progression of atherosclerosis. |
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Authors:
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X Lu; D Lu; U Narayan; V V Kakkar |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Cardiovascular & hematological agents in medicinal chemistry Volume: 9 ISSN: 1875-6182 ISO Abbreviation: Cardiovasc Hematol Agents Med Chem Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-01-04 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101266881 Medline TA: Cardiovasc Hematol Agents Med Chem Country: Netherlands |
Other Details:
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Languages: eng Pagination: 25-41 Citation Subset: IM |
Affiliation:
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Thrombosis Research Institute, Manresa Road, London, SW3 6LR UK. xlu@tri-london.ac.uk. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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