| A role for syndecan-1 and claudin-2 in microbial translocation during HIV-1 infection. | |
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MedLine Citation:
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PMID: 20700059 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Microbial translocation from the gastrointestinal tract has been implicated in chronic activation of the immune system during progressive HIV-1 infection by ill-defined mechanisms. We recently identified a gene encoding syndecan-1 (SYN1) in microarray studies of HIV-1 infection in lymphatic tissues and show here that increased expression of SYN1 in the gut of HIV-1-infected individuals is associated with increased microbial translocation. We further show that: (1) microbial access to SYN1 in the intestinal epithelium could be mediated by compromised barrier function through the upregulation of claudin-2; (2) increases in SYN1 and microbial translocation are associated with systemic immune activation; and (3) SYN1 expression and microbial translocation are inversely correlated with peripheral blood CD4 T-cell counts. We thus propose a new mechanism in which claudin-2 and SYN1 work in concert to enhance microbial translocation across the intestinal epithelial barrier to contribute to chronic immune activation and CD4 T-cell depletion. |
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Authors:
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Anthony J Smith; Timothy W Schacker; Cavan S Reilly; Ashley T Haase |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Journal of acquired immune deficiency syndromes (1999) Volume: 55 ISSN: 1944-7884 ISO Abbreviation: J. Acquir. Immune Defic. Syndr. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-10-15 Completed Date: 2010-11-04 Revised Date: 2011-09-06 |
Medline Journal Info:
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Nlm Unique ID: 100892005 Medline TA: J Acquir Immune Defic Syndr Country: United States |
Other Details:
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Languages: eng Pagination: 306-15 Citation Subset: IM; X |
Affiliation:
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Department of Microbiology, Medical School, University of Minnesota, Minneapolis, MN 55455, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Bacterial Infections / microbiology* Bacterial Translocation* CD4 Lymphocyte Count Female HIV Infections / complications*, immunology* HIV-1 / isolation & purification Humans Male Membrane Proteins / metabolism* Middle Aged Syndecan-1 / metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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R01 AI056997/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/CLDN2 protein, human; 0/Membrane Proteins; 0/Syndecan-1 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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