Document Detail


The role of sleep in directed forgetting and remembering of human memories.
MedLine Citation:
PMID:  21459838     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Ample evidence supports a role for sleep in the offline consolidation of memory. However, circumstances exist where forgetting can be as critical as remembering, both in daily life and clinically. Using a directed forgetting paradigm, here, we investigate the impact of explicit cue instruction during learning, prior to sleep, on subsequent remembering and forgetting of memory, after sleep. We demonstrate that sleep, relative to time awake, can selectively ignore the facilitation of items previously cued to be forgotten, yet preferentially enhance recall for items cued to be remembered; indicative of specificity based on prior waking instruction. Moreover, the success of this differential remember/forget effect is strongly correlated with fast sleep spindles over the left superior parietal cortex. Furthermore, electroencephalography source analysis of these spindles revealed a repeating loop of current density between selective memory-related regions of the superior parietal, medial temporal, and right prefrontal cortices. These findings move beyond the classical notion of sleep universally strengthening information. Instead, they suggest a model in which sleep may be more ecologically attuned to instructions present during learning while awake, supporting both remembering and targeted forgetting of human memories.
Authors:
Jared M Saletin; Andrea N Goldstein; Matthew P Walker
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2011-03-31
Journal Detail:
Title:  Cerebral cortex (New York, N.Y. : 1991)     Volume:  21     ISSN:  1460-2199     ISO Abbreviation:  Cereb. Cortex     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-10-03     Completed Date:  2012-01-23     Revised Date:  2014-09-10    
Medline Journal Info:
Nlm Unique ID:  9110718     Medline TA:  Cereb Cortex     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2534-41     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Electroencephalography
Female
Humans
Male
Memory / physiology*
Polysomnography
Sleep / physiology*
Grant Support
ID/Acronym/Agency:
R01 AG031164/AG/NIA NIH HHS; R01AG031164/AG/NIA NIH HHS
Comments/Corrections

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