| The role of serotonin in respiratory function and dysfunction. | |
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MedLine Citation:
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PMID: 20801236 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Serotonin (5-HT) is a neuromodulator-transmitter influencing global brain function. Past and present findings illustrate a prominent role for 5-HT in the modulation of ponto-medullary autonomic circuits. 5-HT is also involved in the control of neurotrophic processes during pre- and postnatal development of neural circuits. The functional implications of 5-HT are particularly illustrated in the alterations to the serotonergic system, as seen in a wide range of neurological disorders. This article reviews the role of 5-HT in the development and control of respiratory networks in the ponto-medullary brainstem. The review further examines the role of 5-HT in breathing disorders occurring at different stages of life, in particular, the neonatal neurodevelopmental diseases such as Rett, sudden infant death and Prader-Willi syndromes, adult diseases such as sleep apnoea and mental illness linked to neurodegeneration. |
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Authors:
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Gérard Hilaire; Nicolas Voituron; Clément Menuet; Ronaldo M Ichiyama; Hari H Subramanian; Mathias Dutschmann |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review Date: 2010-08-27 |
Journal Detail:
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Title: Respiratory physiology & neurobiology Volume: 174 ISSN: 1878-1519 ISO Abbreviation: Respir Physiol Neurobiol Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-11-01 Completed Date: 2011-03-02 Revised Date: 2011-12-21 |
Medline Journal Info:
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Nlm Unique ID: 101140022 Medline TA: Respir Physiol Neurobiol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 76-88 Citation Subset: IM |
Copyright Information:
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Crown Copyright © 2010. Published by Elsevier B.V. All rights reserved. |
Affiliation:
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Centre de Recherche en Neurobiologie et Neurophysiologie de Marseille (CRN2 M), Unité Mixte de Recherche 6231, CNRS-Université Aix-Marseille II & III, Faculté Saint Jérôme, Marseille, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain / cytology, metabolism Developmental Disabilities / complications, metabolism Humans Nervous System Diseases / complications, metabolism Neurons / metabolism Receptors, Serotonin / metabolism Respiration* Respiration Disorders / metabolism*, pathology, physiopathology Serotonin / chemistry, metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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R33 HL087347-03/HL/NHLBI NIH HHS; R33HL087377/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Serotonin; 50-67-9/Serotonin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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