| The role of the selective serotonin re-uptake inhibitor sertraline in nondepressive patients with chronic ischemic heart failure: a preliminary study. | |
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MedLine Citation:
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PMID: 20487349 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Selective serotonin re-uptake inhibitors (SSRIs) have been associated with better psychiatric status, functional capacity, and fewer arrhythmias in depressive patients with heart failure (HF). In this study, we tested the impact of sertraline (an SSRI) on patients with HF, but not clinical depression. METHODS: We studied 62 clinically stable, nondepressive patients with ischemic HF (New York Heart Association class: I-II), and implantable cardioverter-defibrillator (ICD). Following psychiatric evaluation and quality of life (QoL) assessment, 24-hour electrocardiogram recordings including heart rate variability (HRV) and ICD interrogation were performed every 4 months for 1 year. Ventricular effective refractory period (ERP) at 600-, 500-, and 400-ms cycle length and the inducibility of ventricular tachycardia (VT) were assessed via the ICD. After that, sertraline 50 mg/day was administered for 12 months and the whole evaluation was repeated. RESULTS: Sertraline was associated with fewer ventricular extrasystoles per 24 hours and a significant change in HRV (increase in mean R-R, 5-minute standard deviation of RR intervals, and root mean-square difference of successive RR intervals, and reduction in ultra and very low frequency). It was also followed by an improvement in patients' QoL. A trend toward a decrease was observed in the number of recalled nonsustained VTs. The episodes of sustained VT were not significantly reduced. Ventricular ERPs and VT inducibility remained unaltered. CONCLUSION: In clinically stable, nondepressive patients with ischemic HF and ICD, sertraline is associated with reduced ventricular extrasystoles, better QoL, and a possible improvement in some HRV indexes. This suggests that SSRIs may have a favorable clinical impact on these patients, independent of the improvement in depressive symptoms. |
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Authors:
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Dionyssios Leftheriotis; Panayota Flevari; Ignatios Ikonomidis; Athanasios Douzenis; Chrisovalandis Liapis; Ioannis Paraskevaidis; Efstathios Iliodromitis; Lefteris Lykouras; Dimitrios Th Kremastinos |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Pacing and clinical electrophysiology : PACE Volume: 33 ISSN: 1540-8159 ISO Abbreviation: Pacing Clin Electrophysiol Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-09-30 Completed Date: 2011-02-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7803944 Medline TA: Pacing Clin Electrophysiol Country: United States |
Other Details:
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Languages: eng Pagination: 1217-23 Citation Subset: IM |
Copyright Information:
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©2010, The Authors. Journal compilation ©2010 Wiley Periodicals, Inc. |
Affiliation:
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Department of Cardiology Department of Psychiatry, Attikon University Hospital of Athens, 1 Riministr., Haidari, Athens, Greece. dleftheriotis@yahoo.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Antidepressive Agents / therapeutic use* Chronic Disease Defibrillators, Implantable Depression / psychology Female Heart Failure / drug therapy*, etiology*, psychology Heart Rate / drug effects Humans Male Middle Aged Myocardial Infarction / complications* Quality of Life Refractory Period, Electrophysiological / drug effects Serotonin Uptake Inhibitors / therapeutic use* Sertraline / therapeutic use* Tachycardia, Ventricular / drug therapy Treatment Outcome Ventricular Premature Complexes / drug therapy |
| Chemical | |
Reg. No./Substance:
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0/Antidepressive Agents; 0/Serotonin Uptake Inhibitors; 79617-96-2/Sertraline |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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